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Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
- Dorothea Bestle, M. R. Heindl, E. Böttcher-Friebertshäuser
- Biology, ChemistryLife Science Alliance
- 23 July 2020
It is shown that S can be cleaved by the proprotein convertase furin at the S1/S2 site and the transmembrane serine protease 2 (TMPRSS2) at theS2′ site, and this approach has considerable therapeutic potential for treatment of COVID-19.
Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.
- Natee Jearawiriyapaisarn, H. Moulton, R. Kole
- BiologyMolecular therapy : the journal of the American…
- 1 September 2008
PPMO M23D-B, designed to force skipping of stop-codon containing dystrophin exon 23, is investigated in an mdx mouse model of Duchenne muscular dystrophy, the first report of oligonucleotide-mediated exon skipping and dystrophic protein induction in the heart of treated animals.
Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer
- B. Wu, H. Moulton, Q. Lu
- Biology, MedicineProceedings of the National Academy of Sciences
- 30 September 2008
Systemic delivery of the novel PPMO restores dystrophin to almost normal levels in the cardiac and skeletal muscles in dystrophic mdx mouse, leading to increase in muscle strength and prevents cardiac pump failure induced by dobutamine stress in vivo.
Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.
- H. Moulton, Michelle H. Nelson, S. Hatlevig, M. T. Reddy, P. Iversen
- Biology, ChemistryBioconjugate chemistry
- 28 February 2004
It is shown that conjugation to arginine-rich peptides significantly enhanced the cellular uptake of PMO and R(9)F(2)C was best suited to deliver a PMO to its target RNA resulting in the strongest antisense effect.
Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy.
Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents.
Inhibition of Flavivirus Infections by Antisense Oligomers Specifically Suppressing Viral Translation and RNA Replication
The results suggest that antisense PMO-mediated blocking of cis-acting elements of flavivirus genomes can potentially be developed into an anti-flavivirus therapy.
Chemical Modifications of Antisense Morpholino Oligomers Enhance Their Efficacy against Ebola Virus Infection
- D. Swenson, Kelly L Warfield, S. Bavari
- BiologyAntimicrobial Agents and Chemotherapy
- 17 February 2009
The abilities of two additional VP24-specific PMOs to reduce the cell-free translation of a VP24 reporter, to inhibit the in vitro replication of Ebola virus, and to protect mice against lethal challenge when the PMOs are delivered prior to infection are reported on.