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  • Influence
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
It is shown that S can be cleaved by the proprotein convertase furin at the S1/S2 site and the transmembrane serine protease 2 (TMPRSS2) at theS2′ site, and this approach has considerable therapeutic potential for treatment of COVID-19.
Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.
PPMO M23D-B, designed to force skipping of stop-codon containing dystrophin exon 23, is investigated in an mdx mouse model of Duchenne muscular dystrophy, the first report of oligonucleotide-mediated exon skipping and dystrophic protein induction in the heart of treated animals.
Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer
  • B. Wu, H. Moulton, Q. Lu
  • Biology, Medicine
    Proceedings of the National Academy of Sciences
  • 30 September 2008
Systemic delivery of the novel PPMO restores dystrophin to almost normal levels in the cardiac and skeletal muscles in dystrophic mdx mouse, leading to increase in muscle strength and prevents cardiac pump failure induced by dobutamine stress in vivo.
Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.
It is shown that conjugation to arginine-rich peptides significantly enhanced the cellular uptake of PMO and R(9)F(2)C was best suited to deliver a PMO to its target RNA resulting in the strongest antisense effect.
Inhibition of Flavivirus Infections by Antisense Oligomers Specifically Suppressing Viral Translation and RNA Replication
The results suggest that antisense PMO-mediated blocking of cis-acting elements of flavivirus genomes can potentially be developed into an anti-flavivirus therapy.
Chemical Modifications of Antisense Morpholino Oligomers Enhance Their Efficacy against Ebola Virus Infection
The abilities of two additional VP24-specific PMOs to reduce the cell-free translation of a VP24 reporter, to inhibit the in vitro replication of Ebola virus, and to protect mice against lethal challenge when the PMOs are delivered prior to infection are reported on.