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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These phenotypes correspond… Expand
Nrf2-Keap1 defines a physiologically important stress response mechanism.
The transcription factor Nrf2 regulates the basal and inducible expression of numerous detoxifying and antioxidant genes. The cytoplasmic protein Keap1 interacts with Nrf2 and represses its function.… Expand
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Cancer cells consume large quantities of nutrients and maintain high levels of anabolism. Recent studies revealed that various oncogenic pathways are involved in modulation of metabolism. Nrf2, a key… Expand
A promoter-level mammalian expression atlas
- The Fantom Consortium, Riken Pmii, +261 authors Y. Hayashizaki
- Biology, Computer Science
- 27 March 2014
Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs in mammalian cell-type-specific promoters. Expand
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
- K. Taguchi, H. Motohashi, M. Yamamoto
- Biology, Medicine
- Genes to cells : devoted to molecular & cellular…
- 1 February 2011
The Keap1–Nrf2 regulatory pathway plays a central role in the protection of cells against oxidative and xenobiotic damage. Under unstressed conditions, Nrf2 is constantly ubiquitinated by the… Expand
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress response, metabolic pathways, and innate immunity, and dysregulation of these processes is associated with pathogenic… Expand
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still… Expand
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.
- T. Oyake, K. Itoh, +5 authors K. Igarashi
- Biology, Medicine
- Molecular and cellular biology
- 1 November 1996
Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper (bZip) proteins that can function as transcriptional activators or repressors. The dimer compositions of their… Expand
Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling
- T. Ida, T. Sawa, +13 authors T. Akaike
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 14 April 2014
Significance Reactive sulfur-containing compounds, such as l-cysteine hydropersulfide (CysSSH), reportedly form in mammals. However, the biological relevance of these reactive sulfur species remains… Expand
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system forms the major node of cellular and organismal defense against oxidative and electrophilic stresses of both… Expand