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From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics.
Mass spectrometry (MS) is an established technology in drug metabolite analysis and is now expanding into endogenous metabolite research. Its utility derives from its wide dynamic range, reproducibleExpand
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Mass spectrometry reveals specific and global molecular transformations during viral infection.
Mass spectrometry analysis was used to target three different aspects of the viral infection process: the expression kinetics of viral proteins, changes in the expression levels of cellular proteins,Expand
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Separation of two receptor sites in a single labellar sugar receptor of the flesh-fly by treatment with p-chloromercuribenzoate.
Abstract A 3 min treatment of a single sugar receptor with 0·5 mM p -chloromercuribenzoate (PCMB) did not affect its response to d -fructose, but depressed completely its response to d -glucose. ThisExpand
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Electrogenerated chemiluminescence derivatization reagents for carboxylic acids and amines in high-performance liquid chromatography using tris(2,2'-bipyridine)ruthenium(II).
2-(2-Aminoethyl)-1-methylpyrrolidine and N-(3-aminopropyl)pyrrolidine (NAPP) were found to be selective and sensitive derivatization reagents for carboxylic acid by high-performance liquidExpand
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Effects of sulphhydryl reagents on the labellar sugar receptor of the fleshfly.
Abstract A 5 to 7 min treatment with PCMB dissolved in the phosphate buffer deeply depressed the response of the sugar receptor. The depression was easily recovered by subsequent treatment withExpand
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Electrogenerated chemiluminescence derivatization reagent, 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine, for carboxylic acid in high-performance liquid
3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine (IDHPIA) was found to be a selective and highly sensitive derivatization reagent for carboxylic acid byExpand
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Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response.
To evaluate the precise role of sphingomyelin synthase 2 (SMS2) in sphingomyelin (SM) metabolism and their anti-inflammatory properties, we analyzed species of major SM and ceramide (Cer) (18:1, 18:0Expand
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Glutathione-binding proteins identified by monoclonal antibodies which depress the behavioral response evoked by glutathione in Hydra.
Hydra shows at least 5 components of the behavioral response (R1-R5) which are evoked at different concentrations of S-methylglutathione (GSM). We have prepared several monoclonal antibodies (mAbs),Expand
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Metabolomics relative quantitation with mass spectrometry using chemical derivatization and isotope labeling
Comprehensive detection and quantitation of metabolites from a biological source constitute the major challenges of current metabolomics research. Two chemical derivatization methodologies,Expand
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Effects of divalent cations on 5'-mononucleotidase of bovine cerebral cortex.
A 5′-mononucleotidase preparation partially purified from bovine cerebral cortex was investigated with regard to its interaction with divalent metals. Magnesium, manganese, and zinc ions partly res...
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