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GABAA‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
GABAA‐receptors display an extensive structural heterogeneity based on the differential assembly of a family of at least 15 subunits (α1–6, β1–3, γ1–3, θ, ρl–2) into distinct heteromeric receptorExpand
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
This article does not aim to review in detail the properties of γ-aminobutyric acidA(GABAA)breceptors, because recent accounts of that topic are available. In this same journal, a review of theExpand
NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins
Abstract: Changes in the expression of the NMDA receptor subunits (NRs) NR2A, 2B, and 2C were investigated in histo blots of the developing rat brain with subunit‐specific antisera. At birth, theExpand
Switch in the expression of rat GABAA-receptor subtypes during postnatal development: an immunohistochemical study
The involvement of GABA in neuronal differentiation and maturation precedes its role as inhibitory neurotransmitter in the brain. It was therefore investigated whether GABAA receptors mediating theExpand
GABAB‐receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization
GABAB (γ‐aminobutyric acid)‐receptors have been implicated in central nervous system (CNS) functions, e.g. cognition and pain perception, and dysfunctions including spasticity and absence epilepsy.Expand
Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
Patients with panic disorders show a deficit of GABAA receptors in the hippocampus, parahippocampus and orbitofrontal cortex. Synaptic clustering of GABAA receptors in mice heterozygous for the γ2Expand
The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses.
The gamma2 subunit of GABA(A) receptor chloride channels is required for normal channel function and for postsynaptic clustering of these receptors during synaptogenesis. In addition, GABA(A)Expand
Laminar compartmentalization of GABAA-receptor subtypes in the spinal cord: an immunohistochemical study.
To assess the significance of GABAA-receptor heterogeneity, which is based on a family of at least 15 subunits, the cellular localization and subunit composition of GABAA-receptor subtypes wereExpand
Laminar compartmentalization of GABAA-receptor subtypes in the spinal cord: an immunohistochemical study
To assess the significance of GABAA-receptor heterogeneity, which is based on a family of at least 15 subunits, the cellular localization and subunit composition of GABAA-receptor subtypes wereExpand
Benzodiazepine receptor: demonstration in the central nervous system
Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in theExpand
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