H. Mobley

Publications379
h-index86
Citations29,089
Highly Influential Citations1,463
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Pathogenic Escherichia coli
TLDR
Few microorganisms are as versatile as Escherichia coli; it can also be a highly versatile, and frequently deadly, pathogen. Expand
Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli
TLDR
The complete genome sequence of uropathogenic Escherichia coli, strain CFT073 is presented and Comparisons indicate that extraintestinal pathogenic E. coli arose independently from multiple clonal lineages. Expand
Molecular biology of microbial ureases.
TLDR
The crystal structure of the K. aerogenes enzyme has been determined and provides important insight into the mechanism of catalysis, and accessory genes have been shown to be required for activation of urease apoprotein, and roles for the accessory proteins in metallocenter assembly have been proposed. Expand
Microbial ureases: significance, regulation, and molecular characterization.
TLDR
Urease is a high-molecular-weight, multimeric, nickel-containing enzyme that plays an important role in utilization of environmental nitrogenous compounds and urea-based fertilizers. Expand
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis
TLDR
Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options. Expand
Transcriptome of Uropathogenic Escherichia coli during Urinary Tract Infection
TLDR
This study represents the first assessment of any E. coli pathotype's transcriptome in vivo and provides specific insights into the mechanisms necessary for urinary tract pathogenesis. Expand
Pyelonephritogenic Escherichia coli and killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strains
TLDR
Pyelonephritogenic E. coli strains are more frequently cytotoxic for a putative target, that is, human renal tubular epithelium, than are fecal isolates, and Hemolysin, in some strains, is apparently responsible for this cytotoxicity. Expand
Host–pathogen interactions in urinary tract infection
TLDR
Current research is focused on the identification of additional virulence factors and therapeutic or prophylactic targets that might be used in the generation of vaccines against both uropathogens. Expand
Fitness of Escherichia coli during Urinary Tract Infection Requires Gluconeogenesis and the TCA Cycle
TLDR
It is suggested that peptides and amino acids are the primary carbon source for E. coli during infection of the urinary tract. Expand
Complete Genome Sequence of Uropathogenic Proteus mirabilis, a Master of both Adherence and Motility
TLDR
The complete genome sequence of P. mirabilis HI4320 is reported, a representative strain cultured in the laboratory from the urine of a nursing home patient with a long-term (> or =30 days) indwelling urinary catheter. Expand
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