Pathogenic Escherichia coli
Few microorganisms are as versatile as Escherichia coli; it can also be a highly versatile, and frequently deadly, pathogen.
Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli
- R. Welch, V. Burland, F. Blattner
- BiologyProceedings of the National Academy of Sciences…
- 5 December 2002
The complete genome sequence of uropathogenic Escherichia coli, strain CFT073 is presented and Comparisons indicate that extraintestinal pathogenic E. coli arose independently from multiple clonal lineages.
Molecular biology of microbial ureases.
- H. Mobley, M. D. Island, R. Hausinger
- BiologyMicrobiological reviews
- 1 September 1995
The crystal structure of the K. aerogenes enzyme has been determined and provides important insight into the mechanism of catalysis, and accessory genes have been shown to be required for activation of urease apoprotein, and roles for the accessory proteins in metallocenter assembly have been proposed.
Microbial ureases: significance, regulation, and molecular characterization.
- H. Mobley, R. Hausinger
- BiologyMicrobiological reviews
- 1 March 1989
Urease is a high-molecular-weight, multimeric, nickel-containing enzyme that plays an important role in utilization of environmental nitrogenous compounds and urea-based fertilizers.
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis
- S. Jacobsen, D. Stickler, H. Mobley, M. Shirtliff
- Medicine, BiologyClinical Microbiology Reviews
- 1 January 2008
Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options.
Transcriptome of Uropathogenic Escherichia coli during Urinary Tract Infection
- J. A. Snyder, Brian J. Haugen, H. Mobley
- BiologyInfection and Immunity
- 1 November 2004
This study represents the first assessment of any E. coli pathotype's transcriptome in vivo and provides specific insights into the mechanisms necessary for urinary tract pathogenesis.
Pyelonephritogenic Escherichia coli and killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strains
- H. Mobley, D. M. Green, J. Warren
- Medicine, BiologyInfection and Immunity
- 1 May 1990
Pyelonephritogenic E. coli strains are more frequently cytotoxic for a putative target, that is, human renal tubular epithelium, than are fecal isolates, and Hemolysin, in some strains, is apparently responsible for this cytotoxicity.
Host–pathogen interactions in urinary tract infection
- Greta R. Nielubowicz, H. Mobley
- Biology, MedicineNature reviews. Urology
- 1 August 2010
Current research is focused on the identification of additional virulence factors and therapeutic or prophylactic targets that might be used in the generation of vaccines against both uropathogens.
Complete Genome Sequence of Uropathogenic Proteus mirabilis, a Master of both Adherence and Motility
- Melanie M. Pearson, M. Sebaihia, H. Mobley
- BiologyJournal of Bacteriology
- 28 March 2008
The complete genome sequence of P. mirabilis HI4320 is reported, a representative strain cultured in the laboratory from the urine of a nursing home patient with a long-term (> or =30 days) indwelling urinary catheter.
Genomic Analysis of a Pathogenicity Island in Uropathogenic Escherichia coli CFT073: Distribution of Homologous Sequences among Isolates from Patients with Pyelonephritis, Cystitis, and…
These sequences were found significantly more often in strains associated with the clinical syndromes of acute pyelonephritis and cystitis than in those associated with catheter-associated bacteriuria and in fecal strains of uropathogenic E. coli strains.
...
...