• Publications
  • Influence
Molecular and neuronal substrate for the selective attenuation of anxiety.
TLDR
The findings indicate that the anxiolytic effect of benzodiazepine drugs is mediated by alpha2 GABAA receptors, which are largely expressed in the limbic system, but not by alpha3 GAB AA receptors,Which predominate in the reticular activating system.
Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes
GABAA (γ-aminobutyric acidA) receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension, epileptogenic activity and memory functions, which is evident from the
A new benzodiazepine pharmacology.
TLDR
Rational drug targeting to specific receptor subtypes has now become possible, and only restricted neuronal networks will be modulated by the new subtype-selective drugs.
Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.
GABA(A) (gamma-aminobutyric acid(A)) receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension, epileptogenic activity and memory functions, which is evident from
Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics.
TLDR
The point-mutated knockin mice in which specific GABAA receptor sub types are insensitive to diazepam or some general anesthetics have revealed the specific contribution of individual receptor subtypes to the pharmacological spectrum of diazepAM and general anESThetics.
Specific GABAA Circuits for Visual Cortical Plasticity
TLDR
Only α1-containing circuits were found to drive cortical plasticity, whereas α2-enriched connections separately regulated neuronal firing, which carries implications for models of brain development and the safe design of benzodiazepines for use in infants.
GABAA receptor diversity and pharmacology
  • H. Möhler
  • Biology, Psychology
    Cell and Tissue Research
  • 26 August 2006
TLDR
Specific neuronal networks defined by respective GABAA receptor subtypes can be linked to the regulation of various clearly defined behavioural patterns, of obvious relevance for the pharmacotherapy of certain brain disorders, in particular sleep dysfunctions, anxiety disorders, schizophrenia and diseases associated with memory deficits.
Reversal of pathological pain through specific spinal GABAA receptor subtypes
TLDR
It is shown that their selective activation by the non-sedative (‘α1-sparing’) benzodiazepine-site ligand L-838,417 is highly effective against inflammatory and neuropathic pain yet devoid of unwanted sedation, motor impairment and tolerance development.
GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism.
TLDR
The GABA hypothesis of depression offers new options for antidepressant drug development; cognitive symptoms in schizophrenia are attributed to a cortical GABAergic deficit, and dysfunctional GABAergic inhibition is increasingly understood to contribute to the pathophysiology of autism spectrum disorders.
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