H. Mizuno

Publications62
h-index17
Citations1,092
Highly Influential Citations14
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Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry.
BACKGROUND Breast cancer is one of the most fearful diseases due to its increasing worldwide prevalence. A number of screening tests has been employed including clinical examinations and mammography.… Expand
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Cell-specific localization of alkaloids in Catharanthus roseus stem tissue measured with Imaging MS and Single-cell MS
Significance Terpenoid indole alkaloids are known to be valuable bioactive compounds. In situ RNA hybridization of gene expression of the terpenoid indole alkaloid (TIA) synthetic enzymes has… Expand
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Rhodium(I)-catalyzed direct carboxylation of arenes with CO2 via chelation-assisted C-H bond activation.
Rh-catalyzed direct carboxylation of unactivated aryl C-H bond under atmospheric pressure of carbon dioxide was realized via chelation-assisted C-H activation for the first time. Variously… Expand
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Direct metabolomics for plant cells by live single-cell mass spectrometry
Live single-cell mass spectrometry (live MS) provides a mass spectrum that shows thousands of metabolite peaks from a single live plant cell within minutes. By using an optical microscope, a cell is… Expand
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Live single-cell molecular analysis by video-mass spectrometry.
The direct molecular analysis of a live single cell viewed under a video-microscope has been developed. The cell contents are sucked into a nano-electrospray tip, and hundreds of peaks of ionic… Expand
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Molecular cloning and structural characterization of the human histidase gene (HAL).
Histidase (EC 4.3.1.3) is a cytosolic enzyme that catalyzes the nonoxidative deamination of histidine to urocanic acid. Histidinemia, resulting from reduced histidase activity as reported in… Expand
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Direct drug metabolism monitoring in a live single hepatic cell by video mass spectrometry.
The metabolism of anti-breast cancer drug, tamoxifen, in a single human hepatocellular carcinoma cell, HepG2, was directly monitored by a video-mass spectroscope. The cytoplasm, a vacuole or nucleus… Expand
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Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry.
AIM We investigated the heterogeneity of tafluprost metabolism in primary human hepatocytes at a single-cell level by live single-cell mass spectrometry (MS). MATERIALS & METHODS Picoliter volumes… Expand
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Two mRNA species encoding calcium-dependent protein kinases are differentially expressed in sexual organs of Marchantia polymorpha through alternative splicing.
In plants, calcium-dependent calmodulin-independent protein kinases (CDPKs) are the predominant calcium-regulated protein kinases and their genes are encoded by a multigene family. A CDPK gene was… Expand
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Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts
Ionizing radiation (IR) induces cellular stress responses, such as signal transduction, gene expression, protein modification, and metabolite change that affect cellular behavior. We analyzed… Expand
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