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Cell-specific localization of alkaloids in Catharanthus roseus stem tissue measured with Imaging MS and Single-cell MS

TLDR
The present study showed, using both Imaging mass spectrometry (MS) and Single-cell MS, that many kinds of TIA intermediates, including catharanthine and serpentine, were accumulated in idioblast and laticifer cells of C. roseus stem tissue.
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Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry.

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Direct drug metabolism monitoring in a live single hepatic cell by video mass spectrometry.

TLDR
The metabolism of anti-breast cancer drug, tamoxifen, in a single human hepatocellular carcinoma cell, HepG2, was directly monitored by a video-mass spectroscope, and Unchanged drug molecules were found in cy toplasm and a vacuole, but the metabolites were only found in the cytoplasm.
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Rhodium(I)-catalyzed direct carboxylation of arenes with CO2 via chelation-assisted C-H bond activation.

Rh-catalyzed direct carboxylation of unactivated aryl C-H bond under atmospheric pressure of carbon dioxide was realized via chelation-assisted C-H activation for the first time. Variously…
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Direct metabolomics for plant cells by live single-cell mass spectrometry

TLDR
Live single-cell mass spectrometry (live MS) provides a mass spectrum that shows thousands of metabolite peaks from a single live plant cell within minutes and can be acquired in 10 min.
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Live single-cell molecular analysis by video-mass spectrometry.

TLDR
The direct molecular analysis of a live single cell viewed under a video-microscope has been developed and it is shown that this method is direct and quick to identify the molecules of a cell with simultaneous observation by a Video Microscope.
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Direct single-cell molecular analysis of plant tissues by video mass spectrometry.

TLDR
Direct and quick molecular analysis of live plant single cells viewed under a video-microscope has been developed in their intact undamaged environment using nano-electrospray tip and mass spectrometers, and opens the possibility to compare different cell types from different tissues with morphological evidence in undamaging plants.
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The complexity of intercellular localization of alkaloids revealed by single cell metabolomics.

TLDR
Interestingly, the central TIA intermediate strictosidine also accumulates in both epidermal and idioblast cells of C. roseus, and it is found that vindoline accumulation increases in laticifer cells as the leaf expands, highlighting the complexity of intercellular localization in plant specialized metabolism.
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Risk assessment of diabetes mellitus using dried saliva spot followed by ultra-performance liquid chromatography with fluorescence and mass spectrometry

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Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry.

TLDR
Live single-cell MS successfully detected the heterogeneity of drug metabolism in individual living hepatocytes, and showed that tafluprost metabolism varied among individual cells.
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