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- Publications
- Influence
Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry.
- Takahiro Takayama, Haruhito Tsutsui, +8 authors T. Toyo’oka
- Medicine
- Clinica chimica acta; international journal of…
- 15 January 2016
BACKGROUND
Breast cancer is one of the most fearful diseases due to its increasing worldwide prevalence. A number of screening tests has been employed including clinical examinations and mammography.… Expand
Cell-specific localization of alkaloids in Catharanthus roseus stem tissue measured with Imaging MS and Single-cell MS
- K. Yamamoto, K. Takahashi, +7 authors T. Mimura
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 21 March 2016
Significance Terpenoid indole alkaloids are known to be valuable bioactive compounds. In situ RNA hybridization of gene expression of the terpenoid indole alkaloid (TIA) synthetic enzymes has… Expand
Rhodium(I)-catalyzed direct carboxylation of arenes with CO2 via chelation-assisted C-H bond activation.
- H. Mizuno, J. Takaya, N. Iwasawa
- Chemistry, Medicine
- Journal of the American Chemical Society
- 9 February 2011
Rh-catalyzed direct carboxylation of unactivated aryl C-H bond under atmospheric pressure of carbon dioxide was realized via chelation-assisted C-H activation for the first time. Variously… Expand
Direct metabolomics for plant cells by live single-cell mass spectrometry
- T. Fujii, S. Matsuda, +5 authors T. Masujima
- Chemistry, Medicine
- Nature Protocols
- 27 August 2015
Live single-cell mass spectrometry (live MS) provides a mass spectrum that shows thousands of metabolite peaks from a single live plant cell within minutes. By using an optical microscope, a cell is… Expand
Live single-cell molecular analysis by video-mass spectrometry.
- N. Tsuyama, H. Mizuno, E. Tokunaga, T. Masujima
- Chemistry, Medicine
- Analytical sciences : the international journal…
- 1 May 2008
The direct molecular analysis of a live single cell viewed under a video-microscope has been developed. The cell contents are sucked into a nano-electrospray tip, and hundreds of peaks of ionic… Expand
Molecular cloning and structural characterization of the human histidase gene (HAL).
Histidase (EC 4.3.1.3) is a cytosolic enzyme that catalyzes the nonoxidative deamination of histidine to urocanic acid. Histidinemia, resulting from reduced histidase activity as reported in… Expand
Direct drug metabolism monitoring in a live single hepatic cell by video mass spectrometry.
- Sachiko Date, H. Mizuno, N. Tsuyama, T. Harada, T. Masujima
- Chemistry, Medicine
- Analytical sciences : the international journal…
- 10 March 2012
The metabolism of anti-breast cancer drug, tamoxifen, in a single human hepatocellular carcinoma cell, HepG2, was directly monitored by a video-mass spectroscope. The cytoplasm, a vacuole or nucleus… Expand
Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry.
- Y. Fukano, N. Tsuyama, H. Mizuno, Sachiko Date, M. Takano, T. Masujima
- Chemistry, Medicine
- Nanomedicine
- 20 September 2012
AIM
We investigated the heterogeneity of tafluprost metabolism in primary human hepatocytes at a single-cell level by live single-cell mass spectrometry (MS).
MATERIALS & METHODS
Picoliter volumes… Expand
Two mRNA species encoding calcium-dependent protein kinases are differentially expressed in sexual organs of Marchantia polymorpha through alternative splicing.
- R. Nishiyama, H. Mizuno, +4 authors K. Ohyama
- Medicine, Biology
- Plant & cell physiology
- 1999
In plants, calcium-dependent calmodulin-independent protein kinases (CDPKs) are the predominant calcium-regulated protein kinases and their genes are encoded by a multigene family. A CDPK gene was… Expand
Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts
- Naohiro Tsuyama, H. Mizuno, +5 authors A. Sakai
- Biology, Medicine
- Journal of radiation research
- 16 September 2014
Ionizing radiation (IR) induces cellular stress responses, such as signal transduction, gene expression, protein modification, and metabolite change that affect cellular behavior. We analyzed… Expand