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IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector.
The internal ribosome entry site (IRES) has been widely used to coexpress heterologous gene products by a message from a single promoter. However, little is known about the efficiency ofExpand
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3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.
Although it is expected that hepatocyte-like cells differentiated from human embryonic stem (ES) cells or induced pluripotent stem (iPS) cells will be utilized in drug toxicity testing, the actualExpand
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A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator
Claudin, a tight junction integral membrane protein and a family of proteins, forms the actual sealing element of the tight junction. There are more than 20 members of the claudin family withExpand
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Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction.
Hepatocyte-like cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are expected to be a useful source of cells drug discovery. Although we recently reported thatExpand
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Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems.
To develop nonviral gene vectors that are sufficient for clinical application, it is necessary to understand why and to what extent nonviral vectors are inferior to viral vectors, which in generalExpand
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Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells
Most advanced solid tumors metastasize to different organs. However, no gene therapy effective for multiple tumors has yet been developed. Since a unique characteristic of bone marrow-derivedExpand
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Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex
Quantitative and mechanism-based information on differences in transfection efficiency between viral and non-viral vectors would be highly useful for improving the effectiveness of non-viral vectors.Expand
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Constitutively active PDX1 induced efficient insulin production in adult murine liver.
To generate insulin-producing cells in the liver, recombinant adenovirus containing a constitutively active mutant of PDX1 (PDX1-VP16), designed to activate target genes without the need for proteinExpand
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A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model.
BACKGROUND & AIMS Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one of the nuclear receptors that plays a central role in adipocyte differentiation and insulin sensitivity. PPARExpand
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Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter
ABSTRACT p73 is a p53-related tumor suppressor but is also induced by oncogene products such as E2F-1, raising a question as to whether p73 is a tumor suppressor gene or oncogene. Unlike p53, p73 hasExpand
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