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Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease*
Because of its availability, ease of collection, and correlation with physiology and pathology, urine is an attractive source for clinical proteomics/peptidomics. However, the lack of comparable dataExpand
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Peptide Fingerprinting of Alzheimer's Disease in Cerebrospinal Fluid: Identification and Prospective Evaluation of New Synaptic Biomarkers
Background Today, dementias are diagnosed late in the course of disease. Future treatments have to start earlier in the disease process to avoid disability requiring new diagnostic tools. TheExpand
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Formation and location of glucose oxidase in citric acid producing mycelia of Aspergillus niger
SummaryThe formation and location of glucose oxidase was studied in Aspergillus niger, which was pregrown under citric acid producing conditions. Glucose oxidase could be “de novo” induced by a shiftExpand
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Urine in Clinical Proteomics*
Urine has become one of the most attractive biofluids in clinical proteomics as it can be obtained non-invasively in large quantities and is stable compared with other biofluids. The urinary proteomeExpand
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Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis.
BACKGROUND Non-invasive methods for diagnosis of urothelial carcinoma have reduced specificity in patients with non-malignant genitourinary disease or other disorders. We aimed to use massExpand
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Urinary proteomics in diabetes and CKD.
Urinary biomarkers for diabetes, diabetic nephropathy, and nondiabetic proteinuric renal diseases were sought. For 305 individuals, biomarkers were defined and validated in blinded data sets usingExpand
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Advances in urinary proteome analysis and biomarker discovery.
Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still challenges in clinical nephrology. Definition of biomarkers on the basis of proteome analysis, especially of theExpand
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Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis
We analyzed urinary polypeptides from individuals with neonatal ureteropelvic junction (UPJ) obstruction to predict which individuals with this condition will evolve toward obstruction that needsExpand
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Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy.
BACKGROUND IgA nephropathy (IgAN) is the most common chronic glomerular disease in adults. End-stage renal disease (ESRD) develops in about 30% of the patients. Early intervention and consequentExpand
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Discovery and validation of urinary biomarkers for prostate cancer
Only 30% of patients with elevated serum prostate specific antigen (PSA) levels who undergo prostate biopsy are diagnosed with prostate cancer (PCa). Novel methods are needed to reduce the number ofExpand
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