A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet
A novel fibrinolytic enzyme, named nattokinase, was demonstrated in the vegetable cheese Natto, which is a typical soybean food eaten in Japan, and it digested fibrin but also the plasmin substrate H-D-Val-Leu-Lys-pNA, which was more sensitive to the enzyme than other substrates tried.
Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis
During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, Rac…
A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus.
A strong fibrinolytic enzyme was readily obtained in saline extracts of the earthworm, Lumbricus rubellus, and it hydrolyzed not only plasminogen-rich fibrin plates, but also plasMinogen-free fibrIn plates, which indicated a very broad optimal pH range.
Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus.
From the results of amino acid sequence, amino acid composition analyses and immunological analyses, it was suggested that these six enzyme proteins were derived as isozyme(s) from at least four different genes.
Changes in coagulation and fibrinolysis occurring in dogs during hypothermia.
Purification and characterization of two fibrinolytic enzymes from Bothrops jararaca (jararaca) venom.
Rare Variants of IFIH 1 , a Gene Implicated in Antiviral Responses , Protect Against Type 1 Diabetes
This work thank F. Solary for help with analysis of aging; Y. Mizutani and the Japanese National Bioresource Project for tm strains; and J. Hodgkin for providing strains CB5670, CB6166, CB5439, and CB5430.
Characterization of a cathepsin‐H‐like enzyme from a human melanoma cell line
- H. Tsushima, A. Ueki, Y. Matsuoka, H. Mihara, V. Hopsu-Havu
- Biology, Computer ScienceInternational Journal of Cancer
- 9 July 1991
The melanoma‐derived cathepsin‐H‐like enzyme degrade fibrinogen and fibronectin, but not laminin or type‐IV collagen, and may have important functions in the destruction of extracellular matrix components, thus enabling proliferation, migration, and metastasis to occur.
Studies on blood coagulation and fibrinolysis in patients bitten by Bothrops jararaca (jararaca).
Slower recovery of the haemostatic disturbances after antivenom administration to patients bitten by young snakes suggests a more severe coagulopathy in such accidents, supported by clinical observations.
Distribution of acid stable trypsin inhibitor immunoreactivity in normal and malignant human tissues
The present findings suggest that ASTI could play an important role, not limited to its function as a protease inhibitor, in the invasive growth of malignant neoplasms.