H. Metzger

Publications249
h-index57
Citations12,134
Highly Influential Citations155
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Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.
When aggregated, the high-affinity receptors for IgE on mast cells (Fc epsilon RI) launch a series of phosphorylations, particularly of protein tyrosines. We have analyzed how aggregation initiates… Expand
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Characterization of Gene Expression in Resting and Activated Mast Cells
To characterize gene expression in activated mast cells more comprehensively than heretofore, we surveyed the changes in genetic transcripts by the method of serial analysis of gene expression in the… Expand
  • 113
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Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase.
Aggregation of the receptor with high affinity for IgE (Fc epsilon RI) on the surface of mast cells and basophils stimulates phosphorylation of protein tyrosines, a process in which p53/56lyn kinase… Expand
  • 176
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The receptor with high affinity for immunoglobulin E.
This review is about one of the physiologically important macromolecules that interact with the Fc domains of immunoglobulins. Such substances (complement, "immunoglobulin binding factors," Fc… Expand
  • 464
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Signal transduction by Fc receptors: the Fc&RI case
The family of proteins collectively known as Fc receptors (FcR) plays a variety of roles both in the initiation of the immune response and in its consequences. During the past five years the… Expand
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Stimulation of adenylate cyclase by water-soluble analogues of forskolin.
Analogues of forskolin that are more soluble in water than forskolin have been synthesized and tested for their ability to interact with adenylate cyclase. These analogues are esterified with various… Expand
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Structural basis of antibody function.
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An unusual mechanism for ligand antagonism.
The ratio of late to early events stimulated by the mast cell receptor for immunoglobulin E (IgE) correlated with the affinity of a ligand for the receptor-bound IgE. Because excess receptors… Expand
  • 153
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CHARACTERIZATION OF A HUMAN MACROGLOBULIN. I. THE MOLECULAR WEIGHT OF ITS SUBUNIT.
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Complete structure and expression in transfected cells of high affinity IgE receptor
The high-affinity receptor for immunoglobulin E, Fcɛ RI, is found exclusively on mast cells and basophils. When multivalent aller-gens bind to the receptor-bound IgE, the consequent aggregation of… Expand
  • 470
  • 4