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Chronic musculoskeletal pain and depressive symptoms in the general population. An analysis of the 1st National Health and Nutrition Examination Survey data
TLDR
The findings are based upon the recollection of individuals with respect to the period of 12 months prior to interview and upon the occurrence of depression in the previous week as indicated by the answers to the Depression Scale of the Centre for Epidemiologic Studies (CES‐D). Expand
Randomised trial of oral morphine for chronic non-cancer pain
TLDR
In patients with treatment-resistant chronic regional pain of soft-tissue or musculoskeletal origin, nine weeks of oral morphine in doses up to 120 mg daily may confer analgesic benefit with a low risk of addiction but is unlikely to yield psychological or functional improvement. Expand
The clinical diagnosis of Alzheimer's disease.
TLDR
The sensitivity of diagnosis for dementia of the Alzheimer type (DAT) without any other diagnosis was 87%, and the specificity was 78%, but the ischemic scale score did not discriminate well between patients with pure multi-infarct dementia and those with both DAT and multi- infarCT dementia. Expand
Chronic musculoskeletal pain and depressive symptoms in the national health and nutrition examination I. Epidemiologic follow-up study
TLDR
Follow‐up data on subjects who were examined in two surveys conducted by the United States Center for Health Statistics at an interval of 8 years are reported, finding the strongest relationship found at the NHEFS between the variables examined was between chronic pain and depression. Expand
Prospective study on the relationship between depressive symptoms and chronic musculoskeletal pain
TLDR
The evidence supports both the views that depression promotes pain and pain promotes depression, and chronic pain was the most powerful variable. Expand
A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA
TLDR
New observations include quantitative morphometric evaluations of the hippocampal formation from a longitudinal study of prospectively tested patients and histological and neurochemical data from patients with a clinical presentation consistent with typical Alzheimer's disease, in whom the only neuropathological abnormality was devastating nerve cell loss and gliosis in the hippocampi. Expand
Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis).
TLDR
The results suggest that white matter abnormalities play a role in the development of intellectual impairment in the elderly and may represent a marker for early dementia. Expand
Amitriptyline versus placebo in postherpetic neuralgia
TLDR
Amitriptyline is useful in treating postherpetic neuralgia and may not act as an antidepressant, and good responses were maintained in 12 of 22 patients. Expand
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