• Publications
  • Influence
Nav2/NaG Channel Is Involved in Control of Salt-Intake Behavior in the CNS
Findings suggest that the Nav2 channel plays an important role in the central sensing of body-fluid sodium level and regulation of salt intake behavior. Expand
Metabolism of N-[4-chloro-2-fluoro-5-[(1-methyl-2- propynl)oxy]phenyl]-3,4,5,6-tetrahydrophthalimide (S-23121) in the rat: I. Identification of a new, sulphonic acid type of conjugate.
The same faecal metabolites as those detected in faeces of the rat dosed with 14C-labelled S-23121 were similarly found after dosing with any of the 35S-lab labelled chemicals, implying that the sulphonic acid is incorporated into the double bond after reduction of sulphate to sulphite. Expand
Metabolism of 2,6-Dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl Ether (Pyridalyl) in Rats after Repeated Oral Administration and a Simple Physiologically Based
Analysis of metabolites in tissues revealed that the majority of 14C in perirenal adipose tissue and lungs was pyridalyl, accounting for greater than 90 and 60%, respectively, of the total, whereas a major metabolite in whole blood, kidneys, and liver was a dehalogenated metabolite. Expand
Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces.
The urinary and fecal metabolites of orally administered 2-terT-butyl-4-hydroxyanisole (2-BHA) and 3-tert- butyl-5-methoxy-1,2-benzoquinone ( 2-TBOQ) in rats were identified andjugated metabolites were identified after enzymatic hydrolysis. Expand
Metabolism of 7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482) in rat. 1. Identification of a sulfonic acid type conjugate.
The metabolic pathways of S-53482 in rats are proposed on the basis of the metabolites identified in this study and these pathways were proposed using NMR and MS techniques. Expand
Metabolism of Pyriproxyfen in Rats. 1. Absorption, Disposition, Excretion, and Biotransformation Studies with [phenoxyphenyl-14C]Pyriproxyfen
Male and female rats were given a single oral dose of [phenoxyphenyl- 14 C]pyriproxyfen [4-phenoxyphenyl (R,S)-2-(2-pyridyloxy)propyl ether] at 2 (low dose) or 1000 (high dose) mg/kg. 14 C wasExpand
Metabolism of Pentyl 2-Chloro-4-fluoro-5-(3,4,5,6- tetrahydrophthalimido)phenoxyacetate (Flumiclorac Pentyl, S-23031) in Rats. 1. Identification of Metabolites in Feces and Urine of Rats
Male rats were orally given pentyl 2-chloro-4-fluoro-5-(3,4,5,6-tetrahydrophthalimido)phenoxyacetate (flumiclorac pentyl, S-23031) labeled with 14C at 250 (mg/kg)/day for 6 consecutive days, and se...
Metabolism of Pentyl 2-Chloro-4-fluoro-5-(3,4,5,6-tetrahydrophthal- imido)phenoxyacetate (Flumiclorac Pentyl, S-23031) in Rats. 2. Absorption, Distribution, Biotransformation, and Excretion
Male and female Sprague-Dawley rats, 7 weeks old, were given a single oral dose of [phenyl- 14 C]-S-23031 [pentyl 2-chloro-4-fluoro-5-(3,4,5,6-tetrahydrophthalimido)phenoxyacetate] orExpand
Metabolism of flufenpyr-ethyl in rats and mice.
The metabolism of flufenpyr-ethyl was examined in rats and mice, and a small amount was also formed in the presence of stomach contents, indicating that the parent compound is rapidly metabolized by intestinal contents and blood and liver S9 fractions through ester cleavage. Expand