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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
TLDR
The positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland is described, suggesting a novel pathway that may contribute to the development of type 1 diabetes.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I
TLDR
This channel, which is named growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular pools under basal conditions and augments calcium entry through GRC by regulating trafficking of the channel.
Molecular Cloning of a Novel Brain‐Type Na+‐Dependent Inorganic Phosphate Cotransporter
TLDR
Results indicate that BNPI and DNPI, which coordinate Na+‐dependent Pi transport in the neuron‐rich regions of the brain, may form a new class within the Na+/Pi cotransporter family.
Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor.
TLDR
Results indicate that HGF reduces the acinar cell-like property of AR42J cells and converts them into insulin-producing cells and the effect of HGF was markedly enhanced by activin A.
Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells.
TLDR
It is indicated that betacellulin and activin A convert amylase-secreting AR42J cells into cells secreting insulin, a model system to study the formation of pancreatic endocrine cells.
Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis
TLDR
Activin A is an autocrine activator of PSCs and Follistatin can inhibit PSC activation and collagen secretion by blocking autocrined activin A and decreasing TGF-β expression and secretion of P SCs.
Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type‐1 matrix metalloproteinase on the plasma membrane
TLDR
Data indicate that Ihh promotes PSC migration by enhancing MT1‐MMP localization on the plasma membrane but is negatively regulated by Gli‐1.
Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells.
TLDR
It is demonstrated that EGFR-ERK1/2 is activated following treatment of AGS human gastric carcinoma cells with bile acids, and results suggest that in AGS cells, DC transactivates EGFR through M-BAR- and ADAM/HB-EGF-dependent mechanisms.
Distinct Roles of Smad2-, Smad3-, and ERK-dependent Pathways in Transforming Growth Factor-β1 Regulation of Pancreatic Stellate Cellular Functions*
TLDR
TGF-β1 differentially regulates PSC activation, proliferation, and TGF- β1 mRNA expression through Smad2, Smad3, and ERK-dependent pathways, respectively.
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