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- Publications
- Influence
Evidence for cortical “disconnection” as a mechanism of age-related cognitive decline
- M. O'Sullivan, D. Jones, P. Summers, R. Morris, S. C. Williams, H. Markus
- Psychology, Medicine
- Neurology
- 28 August 2001
Background: Normal aging is accompanied by a decline of cognitive abilities, and executive skills may be affected selectively, but the underlying mechanisms remain obscure and preventive strategies… Expand
Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis
- M. O'Sullivan, R. Morris, B. Huckstep, D. Jones, S. C. Williams, H. Markus
- Psychology, Medicine
- Journal of Neurology, Neurosurgery & Psychiatry
- 1 March 2004
Background: Cerebral small vessel disease is a common cause of vascular dementia. Both discrete lacunar infarcts and more diffuse ischaemic changes, seen as confluent high signal (leukoaraiosis) on… Expand
MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL
- M. O'Sullivan, J. Jarosz, R. Martin, N. Deasy, J. Powell, H. Markus
- Psychology, Medicine
- Neurology
- 13 March 2001
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited, autosomal dominant condition caused by mutations of the Notch3 gene.… Expand
White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
- R. Charlton, T. Barrick, +6 authors H. Markus
- Psychology, Medicine
- Neurology
- 24 January 2006
Background: Damage to white matter tracts, resulting in “cerebral disconnection,” may underlie age-related cognitive decline. Methods: Using diffusion tensor MRI (DTI) to investigate white matter… Expand
Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study
- M. O'Sullivan, P. Summers, D. Jones, J. Jarosz, S. C. Williams, H. Markus
- Medicine
- Neurology
- 26 December 2001
Ischemic leukoaraiosis is a consistent concomitant of vascular dementia. Conventional MRI provides little information about underlying white matter tract disruption and correlates poorly with… Expand
Structural network efficiency is associated with cognitive impairment in small-vessel disease
- A. Lawrence, A. W. Chung, R. Morris, H. Markus, T. Barrick
- Medicine
- Neurology
- 22 July 2014
Objective: To characterize brain network connectivity impairment in cerebral small-vessel disease (SVD) and its relationship with MRI disease markers and cognitive impairment. Methods: A… Expand
White matter structural decline in normal ageing: A prospective longitudinal study using tract-based spatial statistics
- T. Barrick, R. Charlton, C. Clark, H. Markus
- Psychology, Computer Science
- NeuroImage
- 1 June 2010
TLDR
Theory of mind associations with other cognitive functions and brain imaging in normal aging.
- R. Charlton, T. Barrick, H. Markus, R. Morris
- Psychology, Medicine
- Psychology and aging
- 1 June 2009
The study investigated age-related differences in theory of mind and explored the relationship between this ability, other cognitive abilities, and structural brain measures. A cohort of 106 adults… Expand
Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI.
- D. K. Jones, D. Lythgoe, M. Horsfield, A. Simmons, S. Williams, H. Markus
- Medicine
- Stroke
- 1 February 1999
BACKGROUND AND PURPOSE
Information on the neuropathological changes underlying ischemic leukoaraiosis is only available postmortem, and there are limited data on histological appearances early in the… Expand
Blood–brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis
- R. Topakian, T. Barrick, F. Howe, H. Markus
- Medicine
- Journal of Neurology, Neurosurgery & Psychiatry
- 25 August 2009
Background and aim The pathogenesis of cerebral small-vessel disease (SVD) is incompletely understood. Endothelial dysfunction has been implicated and may result in increased blood–brain barrier… Expand