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Evidence for cortical “disconnection” as a mechanism of age-related cognitive decline
Background: Normal aging is accompanied by a decline of cognitive abilities, and executive skills may be affected selectively, but the underlying mechanisms remain obscure and preventive strategiesExpand
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Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis
Background: Cerebral small vessel disease is a common cause of vascular dementia. Both discrete lacunar infarcts and more diffuse ischaemic changes, seen as confluent high signal (leukoaraiosis) onExpand
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MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited, autosomal dominant condition caused by mutations of the Notch3 gene.Expand
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White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
Background: Damage to white matter tracts, resulting in “cerebral disconnection,” may underlie age-related cognitive decline. Methods: Using diffusion tensor MRI (DTI) to investigate white matterExpand
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Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study
Ischemic leukoaraiosis is a consistent concomitant of vascular dementia. Conventional MRI provides little information about underlying white matter tract disruption and correlates poorly withExpand
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Structural network efficiency is associated with cognitive impairment in small-vessel disease
Objective: To characterize brain network connectivity impairment in cerebral small-vessel disease (SVD) and its relationship with MRI disease markers and cognitive impairment. Methods: AExpand
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White matter structural decline in normal ageing: A prospective longitudinal study using tract-based spatial statistics
This study uses DTI techniques to quantify structural integrity change to determine whether regional differences are apparent in the rate of degeneration during longitudinal follow-up in a sample of healthy middle aged and older adults aged between 50 and 90years. Expand
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Theory of mind associations with other cognitive functions and brain imaging in normal aging.
The study investigated age-related differences in theory of mind and explored the relationship between this ability, other cognitive abilities, and structural brain measures. A cohort of 106 adultsExpand
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Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI.
BACKGROUND AND PURPOSE Information on the neuropathological changes underlying ischemic leukoaraiosis is only available postmortem, and there are limited data on histological appearances early in theExpand
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Blood–brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis
Background and aim The pathogenesis of cerebral small-vessel disease (SVD) is incompletely understood. Endothelial dysfunction has been implicated and may result in increased blood–brain barrierExpand
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