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Interneurons of the neocortical inhibitory system
Mammals adapt to a rapidly changing world because of the sophisticated cognitive functions that are supported by the neocortex. The neocortex, which forms almost 80% of the human brain, seems to haveExpand
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Real-Time Computing Without Stable States: A New Framework for Neural Computation Based on Perturbations
A key challenge for neural modeling is to explain how a continuous stream of multimodal input from a rapidly changing environment can be processed by stereotypical recurrent circuits ofExpand
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Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, theExpand
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The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability.
  • M. Tsodyks, H. Markram
  • Psychology, Materials Science
  • Proceedings of the National Academy of Sciences…
  • 21 January 1997
Although signaling between neurons is central to the functioning of the brain, we still do not understand how the code used in signaling depends on the properties of synaptic transmission.Expand
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Differential signaling via the same axon of neocortical pyramidal neurons.
The nature of information stemming from a single neuron and conveyed simultaneously to several hundred target neurons is not known. Triple and quadruple neuron recordings revealed that each synapticExpand
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Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex.
1. Dual voltage recordings were made from pairs of adjacent, synaptically connected thick tufted layer 5 pyramidal neurones in brain slices of young rat (14‐16 days) somatosensory cortex to examineExpand
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Neural Networks with Dynamic Synapses
Transmission across neocortical synapses depends on the frequency of presynaptic activity (Thomson & Deuchars, 1994). Interpyramidal synapses in layer V exhibit fast depression of synapticExpand
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Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex.
A puzzling feature of the neocortex is the rich array of inhibitory interneurons. Multiple neuron recordings revealed numerous electrophysiological-anatomical subclasses of neocorticalExpand
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The Blue Brain Project
  • H. Markram
  • Psychology, Medicine
  • Nature Reviews Neuroscience
  • 1 February 2006
IBM's Blue Gene supercomputer allows a quantum leap in the level of detail at which the brain can be modelled. I argue that the time is right to begin assimilating the wealth of data that has beenExpand
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Disynaptic Inhibition between Neocortical Pyramidal Cells Mediated by Martinotti Cells
Reliable activation of inhibitory pathways is essential for maintaining the balance between excitation and inhibition during cortical activity. Little is known, however, about the activation of theseExpand
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