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Interneurons of the neocortical inhibitory system
This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits. Expand
Real-Time Computing Without Stable States: A New Framework for Neural Computation Based on Perturbations
A new computational model for real-time computing on time-varying input that provides an alternative to paradigms based on Turing machines or attractor neural networks, based on principles of high-dimensional dynamical systems in combination with statistical learning theory and can be implemented on generic evolved or found recurrent circuitry. Expand
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of post Synaptic action potentials and unitary excitatory postsynaptic potentials was found to induce changes in EPSPs. Expand
The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability.
  • M. Tsodyks, H. Markram
  • Biology, Materials Science
  • Proceedings of the National Academy of Sciences…
  • 21 January 1997
By setting the rate of synaptic depression, release probability is an important factor in determining the neural code, suggesting that the relative contribution of rate and temporal signals varies along a continuum. Expand
Differential signaling via the same axon of neocortical pyramidal neurons.
Differential signaling is a key mechanism in neocortical information processing, which can be regulated by selective synaptic modifications, andeterogeneity of synaptic transfer functions allows multiple synaptic representations of the same presynaptic action potential train and suggests that these synaptic representations are regulated in a complex manner. Expand
Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex.
Dual voltage recordings were made from pairs of adjacent, synaptically connected thick tufted layer 5 pyramidal neurones in brain slices of young rat (14‐16 days) somatosensory cortex to examine the physiological properties of unitary EPSPs and the axonal and dendritic anatomy of both projecting and target neurones was uniform. Expand
Neural Networks with Dynamic Synapses
A unified phenomenological model is proposed that allows computation of the postsynaptic current generated by both types of synapses when driven by an arbitrary pattern of action potential activity in a presynaptic population and allows for derivation of mean-field equations, which govern the activity of large, interconnected networks. Expand
Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex.
It is suggested that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable combinatorial inhibitory effects in the neocortex. Expand
The Blue Brain Project
  • H. Markram
  • Psychology, Medicine
  • Nature Reviews Neuroscience
  • 1 February 2006
It is argued that the time is right to begin assimilating the wealth of data that has been accumulated over the past century and start building biologically accurate models of the brain from first principles to aid the understanding of brain function and dysfunction. Expand
Disynaptic Inhibition between Neocortical Pyramidal Cells Mediated by Martinotti Cells
A disynaptic inhibitory pathway among neocortical pyramidal cells (PCs) is reported and proposed as a central mechanism for regulation of cortical activity. Expand