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Central retinal artery occlusion: local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial.
PURPOSE The reported outcomes of central retinal artery occlusion (CRAO) with or without treatment vary considerably. Although local intra-arterial fibrinolysis (LIF) using recombinant tissueExpand
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Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. EAGLE Study report no. 1
BackgroundThe natural course of central retinal artery occlusion (CRAO) often leads to legal blindness in the affected eye. To date, none of the conservative therapies had proven effective inExpand
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The pharmacokinetics of a 1-h paclitaxel infusion
Purpose: To characterize the disposition of paclitaxel (PAC) after a 1-h infusion in humans and define if possible a pharmacodynamic relationship between PAC disposition and the observed toxicity.Expand
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Good clinical practice: historical background and key aspects.
Clinical research trials (both academic and industry sponsored) are increasingly playing a role in various medical disciplines, including younger fields of clinical trial interest, such as nuclearExpand
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Die 12. Novelle des Arzneimittelgesetzes in Deutschland
ZusammenfassungDie Richtlinie 2001/20/EG des Europäischen Parlaments und des Rates vom April 2001—die so genannte Clinical Trials Directive—wurde im August 2004 in Deutschland in Form der 12. NovelleExpand
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Phase I study of paclitaxel administered as a 1-hour infusion: toxicity and pharmacokinetics.
Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) is one of the most important new drugs used in the treatment of solid tumors. Use of paclitaxel, however, is associated with someExpand
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Clinical phase I study with one-hour paclitaxel infusion.
BACKGROUND Paclitaxel (PAC) is one of the major anti-cancer drugs, effective in different tumors. Studies with 24-hour infusion with 135 mg/m2 and a three-hour infusion with 175 mg/m2 showed aExpand
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Comparative pharmacokinetics and relative bioavailability for different preparations of nitrofurantoin.
In a single-dose study three different dosage forms of nitrofurantoin tablets are compared in order to attain a longer duration of efficacy by means of sustained-release dosage forms. In particular,Expand
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[The 12th amendment to the German Drug Law. Chances and obstacles for investigator-initiated clinical trials].
The European Union's so called Clinical Trials Directive 2001/20/EC was implemented in national law in Germany in August 2004, leading to the 12th amendment of the German Drug LawExpand
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Benidipine hydrochloride--a new calcium-channel blocker of the dihydropyridine type. Pharmacokinetics, pharmacodynamics, tolerance and dose finding in mild to moderate hypertension.
(+/-)-(R*)-2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3, 5-dicarboxylic acid (R*)-1-benzyl-3-piperidinyl ester, methyl ester hydrochloride (benidipine hydrochloride, KW-3049) is a newlyExpand
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