Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
- H. Luesch, R. Moore, V. Paul, S. Mooberry, T. Corbett
- Chemistry, BiologyJournal of Natural Products
- 28 June 2001
The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report its isolation from the marine cyanobacterium Symploca sp. VP642 from…
A genomic screen for activators of the antioxidant response element
- Yanxia Liu, J. Kern, J. Walker, Jeffrey A. Johnson, P. Schultz, H. Luesch
- BiologyProceedings of the National Academy of Sciences
- 20 March 2007
Overexpression of cDNAs conferred partial resistance to hydrogen peroxide or rotenone-induced toxicity, consistent with the induction of antioxidant and phase II detoxification enzymes, which can protect from oxidative stress.
Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula.
- H. Luesch, W. Yoshida, R. Moore, V. Paul, T. Corbett
- Chemistry, BiologyJournal of the American Chemical Society
- 15 May 2001
Apratoxin A (1), a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont; however, it was only marginally active in vivo against a colon tumor and ineffective against a mammary tumor.
Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium lyngbya majuscula.
- H. Luesch, W. Yoshida, R. Moore, V. Paul, S. Mooberry
- Chemistry, BiologyJournal of Natural Products
- 13 April 2000
The isolation of 1 from L. majuscula once more supports the proposal that many compounds originally isolated from the sea hare Dolabella auricularia are of cyanobacterial origin and was shown to be a potent disrupter of the cellular microfilament network.
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
- K. Taori, V. Paul, H. Luesch
- Chemistry, BiologyJournal of the American Chemical Society
- 19 January 2008
A novel cytotoxic cyclodepsipeptide isolated from the marine cyanobacterium Symploca sp.
Marine natural products: a new wave of drugs?
- Rana Montaser, H. Luesch
- Chemistry, BiologyFuture Medicinal Chemistry
- 1 September 2011
This work illustrates the high degree of innovation in the field of marine natural products, which in its view will lead to a new wave of drugs that flow into the market and pharmacies in the future.
Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula.
- H. Luesch, R. Pangilinan, W. Yoshida, R. Moore, V. Paul
- Chemistry, BiologyJournal of Natural Products
- 13 February 2001
Two new cyclodepsipeptides have been isolated from a population of the marine cyanobacterium Lyngbya majuscula collected at Piti Bomb Holes, Guam and exhibit weak cytotoxicity against LoVo cancer cells, but possess moderate antimycobacterial activity and stimulate elastase activity.
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
- H. Teo, Sourav Ghosh, V. Tergaonkar
- BiologyNature Cell Biology
- 1 August 2010
The first cytoplasmic role of Rap1 is identified and a mechanism through which it regulates an important signalling cascade in mammals, independent of its ability to regulate telomere function is provided.
Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam.
- S. Matthew, Lilibeth A. Salvador, P. Schupp, V. Paul, H. Luesch
- Chemistry, BiologyJournal of Natural Products
- 24 September 2010
Collections of the marine cyanobacterium Lyngbya bouillonii from shallow patch reefs in Apra Harbor, Guam, afforded three hitherto undescribed analogues of the glycosidic macrolide lyngbyaloside,…
Biosynthesis of 4-methylproline in cyanobacteria: cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities.
- H. Luesch, D. Hoffmann, J. Hevel, J. Becker, T. Golakoti, R. Moore
- BiologyJournal of Organic Chemistry
- 10 January 2003
The biosynthesis of the unusual amino acid 4-methylproline in the Nostoc genus of cyanobacteria was investigated on the genetic and enzymatic level and deuterium labeling studies were carried out to reveal the stereospecificities of the enzyme reactions.
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