H. Luesch

Publications196
h-index49
Citations7,124
Highly Influential Citations150
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Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
TLDR
A novel cytotoxic cyclodepsipeptide isolated from the marine cyanobacterium Symploca sp.
A genomic screen for activators of the antioxidant response element
TLDR
Overexpression of cDNAs conferred partial resistance to hydrogen peroxide or rotenone-induced toxicity, consistent with the induction of antioxidant and phase II detoxification enzymes, which can protect from oxidative stress.
Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report its isolation from the marine cyanobacterium Symploca sp. VP642 from…
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
TLDR
The first cytoplasmic role of Rap1 is identified and a mechanism through which it regulates an important signalling cascade in mammals, independent of its ability to regulate telomere function is provided.
Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses.
TLDR
The results suggest that in human cultured cells R. rosea does not act as an antioxidant and that its mode of action cannot be sufficiently explained through a pro-oxidant hormetic mechanism.
Marine natural products: a new wave of drugs?
TLDR
This work illustrates the high degree of innovation in the field of marine natural products, which in its view will lead to a new wave of drugs that flow into the market and pharmacies in the future.
Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula.
TLDR
Apratoxin A (1), a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont; however, it was only marginally active in vivo against a colon tumor and ineffective against a mammary tumor.
New apratoxins of marine cyanobacterial origin from Guam and Palau.
Two collections of the marine cyanobacterium Lyngbya sp. from Guam and Palau that both afforded the potent cytotoxin apratoxin A (1) each yielded different structural analogues with lower degrees of…
A functional genomics approach to the mode of action of apratoxin A
TLDR
It is concluded that apratoxin A mediates its antiproliferative activity through the induction of G1 cell cycle arrest and an apoptotic cascade, which is at least partially initiated through antagonism of FGF signaling via STAT3.
Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium lyngbya majuscula.
TLDR
The isolation of 1 from L. majuscula once more supports the proposal that many compounds originally isolated from the sea hare Dolabella auricularia are of cyanobacterial origin and was shown to be a potent disrupter of the cellular microfilament network.
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