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Molecular Cell Biology
Molecular cell biology , Molecular cell biology , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte
MicroRNAs Modulate Hematopoietic Lineage Differentiation
TLDR
The results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other micro RNAs have similar regulatory roles during other facets of vertebrate development.
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.
TLDR
Daily administration of a very low dose of gAcrp30 to mice consuming a high-fat/sucrose diet caused profound and sustainable weight reduction without affecting food intake.
Oxidized redox state of glutathione in the endoplasmic reticulum.
TLDR
Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.
Role of transforming growth factor beta in human disease.
TLDR
In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular matrix, which is clearly evident in the interactions mediated by the cytokine transforming growth factor β (TGF-β).
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.
TLDR
Four somatic gain-of-function mutations affecting JAK2 exon 12 define a distinctive myeloproliferative syndrome that affects patients who currently receive a diagnosis of polycythemia vera or idiopathic erythrocytosis.
Myogenic factors that regulate expression of muscle-specific microRNAs.
TLDR
This work suggests that induction of these microRNAs is important in regulating the expression of muscle-specific proteins, and demonstrates that the myogenic factors Myogenin and MyoD bind to regions upstream of thesemicroRNAs and are likely to regulate their expression.
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