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The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications
TLDR
The present report summarizes 20 years of technique development and study results pertinent to the characterization of ONH connective tissue deformation and remodeling in the unilateral monkey experimental glaucoma (EG) model and proposes that the defining pathophysiology of aglaucomatous optic neuropathy involves deformation, remodeling, and mechanical failure of the ONH connections. Expand
The Connective Tissue Components of Optic Nerve Head Cupping in Monkey Experimental Glaucoma Part 1: Global Change.
TLDR
The authors' postmortem studies retrospectively identify five connective tissue components of ONH "cupping" in monkey EG which serve as targets for longitudinally staging and phenotyping ONH connectives tissue alteration within all forms of monkey and human optic neuropathy. Expand
Lamina cribrosa microarchitecture in normal monkey eyes part 1: methods and initial results.
TLDR
The authors' data support previous characterizations of diminished connective tissue density within the ST and IT ONH regions and support the clinical importance of eye-specific LMA discordance warrants further study. Expand
Lamina Cribrosa Microarchitecture in Monkey Early Experimental Glaucoma: Global Change
TLDR
Pore diameter, CTV, and LV increase in monkey early EG; however, EG eye-specific change is variable and includes both increases and decreases in BD and CTVF. Expand
3D Histomorphometric Reconstruction and Quantification of the Optic Nerve Head Connective Tissues.
TLDR
The methods for the high-resolution, digital, 3D histomorphometric reconstruction of the optic nerve head tissues are summarized, including their visualization, parameterization, and quantification, and their use to determine animal-specific and experiment-wide experimental glaucoma versus Control eye differences in the unilateral, monkey experimental glAUcoma model. Expand
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