The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial
In elderly hypertensive patients, a slightly more effective blood pressure reduction during candesartan-based therapy, compared with control therapy, was associated with a modest, statistically non-significant, reduction in major cardiovascular events and with a marked reduction in non-fatal stroke.
Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system.
It is hypothesized that the metabolic abnormalities linked to the hypertension by a pathophysiologic process that involves the sympathoadrenal system and exerts influence on blood pressure and complications in many patients.
Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15 000 Swedish men and women born 1915-29
This study provides by far the most persuasive evidence of a real association between size at birth and mortality from ischaemic heart disease in men, which cannot be explained by methodological artefact or socioeconomic confounding and strongly suggests that it is variation in fetal growth rate rather thansize at birth that is aetiologically important.
Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years
It is confirmed that reduced fetal growth is associated with increased risk of diabetes and suggest a specific association with thinness at birth and this relation seems to be mediated through insulin resistance rather than through impaired β cell function and to depend on an interaction with obesity in adult life.
Serum retinol levels and the risk of fracture.
- K. Michaëlsson, H. Lithell, B. Vessby, H. Melhus
- MedicineNew England Journal of Medicine
- 23 January 2003
The findings suggest that current levels of vitamin A supplementation and food fortification in many Western countries may need to be reassessed.
Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance.
- J. Holte, T. Bergh, C. Berne, L. Berglund, H. Lithell
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 May 1994
It is concluded that the early insulin response to glucose was increased in women with PCOS, not accounted for by insulin resistance, closely associated to the increased androgenicity, and present also at low-normal BMI.
Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome.
- J. Holte, T. Bergh, C. Berne, L. Wide, H. Lithell
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 September 1995
Insulin resistance in obese women with PCOS was reduced by weight loss to similar levels as BMI-matched control subjects, suggesting that insulin resistance in PCOS is not a feature of PCOS per se.
A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension.
Hydchlorothiazide for the treatment of essential hypertension has adverse effects on glucose and lipid metabolism and it is possible, but not proved, that these changes may contribute to the risk for diabetes mellitus and coronary heart disease.
Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men.
- L. Kilander, H. Nyman, M. Boberg, L. Hansson, H. Lithell
- Medicine, PsychologyHYPERTENSION
- 1 March 1998
Analysis of data from a general population of healthy elderly men indicates that hypertension and associated metabolic disturbances might be susceptibility factors for cognitive disorders, and adds support to possibilities of intervention in early stages in cognitive decline, ie, before manifest dementia.
Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action.
- B. Kiens, H. Lithell, K. Mikines, E. Richter
- Medicine, BiologyJournal of Clinical Investigation
- 1 October 1989
Investigation of the effects of exercise and a physiological increase in plasma insulin concentration on muscle lipoprotein lipase activity, leg exchange of glucose, and serum lipoproteins concluded that physiological concentrations of insulin decrease m-LPLA in proportion to the effect of insulin on muscle glucose uptake, while muscle contractions cause a local, delayed, and transient increase in m- LPLA.