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EBF2 determines and maintains brown adipocyte identity.
The master transcription factor Pparγ regulates the general differentiation program of both brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat lineage-specificExpand
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Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue
Significance Obesity has reached pandemic levels, prompting the need for novel therapeutics. The immune system has been suggested to be critically linked to metabolic health, leading to the prospectExpand
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Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brownExpand
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Ebf2 is a selective marker of brown and beige adipogenic precursor cells
Significance High levels of brown/beige fat activity protects animals against metabolic disease, but there has been little known about the precursor cells that mediate the expansion of brown or beigeExpand
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Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.
Glucocorticoids (GCs) are commonly prescribed drugs, but their anti-inflammatory benefits are mitigated by metabolic side effects. Their transcriptional effects, including tissue-specific geneExpand
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PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.
PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear.Expand
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Nuclear Receptor Corepressors are Required for the Histone Deacetylase Activity of HDAC3 In Vivo
Histone deacetylase 3 (HDAC3) is an epigenome-modifying enzyme that is required for normal mouse development and tissue-specific functions. In vitro, HDAC3 protein itself has minimal enzyme activityExpand
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Histone Deacetylase 3 Prepares Brown Adipose Tissue For Acute Thermogenic Challenge
Brown adipose tissue is a thermogenic organ that dissipates chemical energy as heat to protect animals against hypothermia and to counteract metabolic disease. However, the transcriptional mechanismsExpand
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Efficient Initial Pool Generation for Weighted Graph Problems Using Parallel Overlap Assembly
We introduce and compare parallel overlap assembly with the hybridization/ligation method to solve a graph problem with weighted edges. Expand
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Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers.
Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its widespread clinical use. Rosi functions as a high-affinity ligand for peroxisomeExpand
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