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Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN
TLDR
An anatomically distinct population of ‘giant’, melanopsin-expressing ganglion cells in the primate retina that, in addition to being intrinsically photosensitive, are strongly activated by rods and cones, and display a rare, S-Off, (L + M)-On type of colour-opponent receptive field. Expand
Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
TLDR
It is shown that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs, most likely the visual pigment of phototransducing R GCs that set the circadian clock and initiate other non–image-forming visual functions. Expand
Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision
TLDR
It is indicated that light signals for irradiance detection are dissociated from pattern vision at the retinal ganglion cell level, and animals that cannot detect light for NIF functions are still capable of image formation. Expand
Melanopsin‐expressing ganglion cells on macaque and human retinas form two morphologically distinct populations
TLDR
The results of anatomical studies using the polyclonal antibody specifically against human melanopsin that confirm and extend previous descriptions of melanopigment cells in primates are reported. Expand
Photon capture and signalling by melanopsin retinal ganglion cells
TLDR
Fundamental parameters governing intrinsic light responses and associated spike generation of retinal ganglion cells are reported, finding that a flash causing a few hundred isomerized melanopsin molecules in a retina is sufficient for reaching threshold for the pupillary light reflex. Expand
Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea
TLDR
The findings reveal a light-sensing function for mammalian OPN5, until now an orphan opsin in mammals, and the mouse corneal circadian rhythm is also photoentrainable ex vivo, and thisphotoentrainment likewise requires OPN 5. Expand
Parietal-Eye Phototransduction Components and Their Potential Evolutionary Implications
TLDR
The discovery of two opsins in the same cell: the blue-sensitive pinopsin and a previously unidentified green-sensitive opsin, which is named parietopsin provides clues about how rod and cone phototransduction might have evolved. Expand
Non-image-forming ocular photoreception in vertebrates
TLDR
The main function of the inner-retina photoreceptors is to generate and transmit non-image-forming visual information, although some role in conventional vision (image detection) is also possible. Expand
Intrinsically photosensitive retinal ganglion cells detect light with a vitamin A-based photopigment, melanopsin.
TLDR
Study of mice lacking RPE65, a protein essential for the regeneration of rod and cone pigments, and exogenous all-trans-retinal was also able to rescue the low sensitivity of rpe65-/- ipRGCs suggest melanopsin could be a bistable pigment. Expand
In vivo gene delivery in the retina using polyethylenimine.
TLDR
The successful use of a polymer as a carrier to deliver shRNA-expressing plasmid DNA to retinal ganglion cells in vivo and hypothesized that knocking down melanopsin in the wild-type mouse retina should produce a similar phenotype. Expand
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