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Dlic1 deficiency impairs ciliogenesis of photoreceptors by destabilizing dynein
Cytoplasmic dynein 1 is fundamentally important for transporting a variety of essential cargoes along microtubules within eukaryotic cells. However, in mammals, few mutants are available for studying… Expand
Tomato UV-B receptor SlUVR8 mediates plant acclimation to UV-B radiation and enhances fruit chloroplast development via regulating SlGLK2
Plants utilize energy from sunlight to perform photosynthesis in chloroplast, an organelle that could be damaged by solar UV radiation. The ultraviolet-B (UV-B) photoreceptor UVR8 is required for… Expand
Tomato MBD5, a methyl CpG binding domain protein, physically interacting with UV-damaged DNA binding protein-1, functions in multiple processes.
In tomato (Solanum lycopersicum), high pigment mutations (hp-1 and hp-2) were mapped to genes encoding UV-damaged DNA binding protein 1 (DDB1) and de-etiolated-1 (DET1), respectively. Here we… Expand
Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death‐associated protein like‐1 DAPL1 by alternative MITF splice forms
Vertebrate eye development and homoeostasis critically depend on the regulation of proliferation of cells forming the retinal pigment epithelium (RPE). Previous results indicated that the… Expand
Effectiveness of four tonometers in measuring intraocular pressure following femtosecond laser-assisted LASIK, SMILE and transepithelial PRK.
- S. Chen, Bernardo T Lopes, +9 authors A. Elsheikh
- Journal of cataract and refractive surgery
- 3 April 2020
PURPOSE To test the performance of 4 tonometers in estimating intraocular pressure (IOP) after 3 forms of refractive surgery. SETTING Eye Hospital, WenZhou Medical University, China. DESIGN… Expand
Microphthalmia-associated transcription factor acts through PEDF to regulate RPE cell migration.
Cells of the retinal pigment epithelium (RPE) play major roles in metabolic functions, maintenance of photoreceptor function, and photoreceptor survival in the retina. They normally form a stable… Expand
Graphene Oxide Dysregulates Neuroligin/NLG-1-Mediated Molecular Signaling in Interneurons in Caenorhabditis elegans
Graphene oxide (GO) can be potentially used in many medical and industrial fields. Using assay system of Caenorhabditis elegans, we identified the NLG-1/Neuroligin-mediated neuronal signaling… Expand
Allele‐specific genetic interactions between Mitf and Kit affect melanocyte development
The tyrosine kinase receptor KIT and the transcription factor MITF, each required for melanocyte development, have been shown to interact functionally both in vitro and in vivo. In vitro, KIT… Expand
Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium
Regeneration of the visual pigment by cells of the retinal pigment epithelium (RPE) is fundamental to vision. Here we show that the microphthalmia-associated transcription factor, MITF, which plays a… Expand
The transcription factor MITF in RPE function and dysfunction
- X. Ma, H. Li, Y. Chen, J. Yang, Ling Hou
- Biology, Medicine
- Progress in Retinal and Eye Research
- 23 June 2019
Dysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks of retinal degenerative diseases in mammals. A critical transcription factor for RPE development and function is the… Expand