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Large-scale mapping of human protein–protein interactions by mass spectrometry
Mapping protein–protein interactions is an invaluable tool for understanding protein function. Here, we report the first large‐scale study of protein–protein interactions in human cells using a mass… Expand
Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. This… Expand
Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia.
Iron maldistribution has been implicated in multiple diseases, including the anemia of inflammation (AI), atherosclerosis, diabetes, and neurodegenerative disorders. Iron metabolism is controlled by… Expand
Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
- L. Yang, H. Li, +4 authors Y. Liu
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 1 May 2008
Metallothionein (MT) as a potent antioxidant can affect energy metabolism. The present study was undertaken to investigate the association between MT gene polymorphism and type 2 diabetes mellitus.… Expand
ICE1 demethylation drives the range expansion of a plant invader through cold tolerance divergence
Cold tolerance adaption is a crucial determinant for the establishment and expansion of invasive alien plants into new cold environments; however, its evolutionary mechanism is poorly understood.… Expand
Transferrin/transferrin receptor-mediated drug delivery.
Since transferrin was discovered more than half a century ago, a considerable effort has been made towards understanding tranferrin-mediated iron uptake. However, it was not until recently with the… Expand
Photoreceptor Coupling Is Controlled by Connexin 35 Phosphorylation in Zebrafish Retina
Electrical coupling of neurons is widespread throughout the CNS and is observed among retinal photoreceptors from essentially all vertebrates. Coupling dampens voltage noise in photoreceptors and… Expand
Nitrification performance and microbial community dynamics in a submerged membrane bioreactor with complete sludge retention.
A submerged membrane bioreactor (MBR) supplied with inorganic ammonium-bearing wastewater (NH(4)(+)-N, 500 mgl(-1)) was operated for 260 days without sludge purge under decreased hydraulic retention… Expand
A simple and efficient method for purification of intact white spot syndrome virus (WSSV) viral particles.
A new simple and efficient method for isolation of intact WSSV viral particles from infected crayfish tissues with high yield was developed. Abundant viral particles could be obtained with only a few… Expand
Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.
- V. Bhalla, Dorothée Daidié, +7 authors D. Pearce
- Biology, Medicine
- Molecular endocrinology
- 1 December 2005
Serum- and glucocorticoid-regulated kinase 1 (SGK1) is an aldosterone-regulated early response gene product that regulates the activity of several ion transport proteins, most notably that of the… Expand