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Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease Mice
Huntington's disease (HD) is characterized by the selective loss of striatal projection neurons. In early stages of HD, neurodegeneration preferentially occurs in the lateral globus pallidus (LGP)Expand
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Interaction of Huntington Disease Protein with Transcriptional Activator Sp1
  • S. Li, A. Cheng, +4 authors X. Li
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 1 March 2002
ABSTRACT Polyglutamine expansion causes Huntington disease (HD) and at least seven other neurodegenerative diseases. In HD, N-terminal fragments of huntingtin with an expanded glutamine tract areExpand
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Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
Huntington disease (HD) is caused by expansion of a glutamine repeat in the amino-terminal region of huntingtin. Despite its widespread expression, mutant huntingtin induces selective neuronal lossExpand
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Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation.
Vascular cell adhesion molecule-1 (VCAM-1) is expressed on vascular endothelium in a variety of inflammatory conditions and mediates leukocyte recruitment from blood into tissues. In this study weExpand
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Kainate receptor-mediated heterosynaptic facilitation in the amygdala
Prolonged low-frequency stimulation of excitatory afferents to basolateral amygdala neurons results in enduring enhancement of excitatory synaptic responses. The induction of this form of synapticExpand
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Fast Mode Decision Algorithm for Inter-Frame Coding in Fully Scalable Video Coding
  • H. Li, Z. Li, C. Wen
  • Computer Science
  • IEEE Transactions on Circuits and Systems for…
  • 1 July 2006
Scalable video coding is an ongoing standard, and the current working draft (WD) is an extension of H.264/AVC. In the WD, an exhaustive search technique is employed to select the best coding mode forExpand
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Stress Impairs α1A Adrenoceptor-Mediated Noradrenergic Facilitation of GABAergic Transmission in the Basolateral Amygdala
Intense or chronic stress can produce pathophysiological alterations in the systems involved in the stress response. The amygdala is a key component of the brain's neuronal network that processes andExpand
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Stress Impairs 5-HT2A Receptor-Mediated Serotonergic Facilitation of GABA Release in Juvenile Rat Basolateral Amygdala
The occurrence of stress and anxiety disorders has been closely associated with alterations of the amygdala GABAergic system. In these disorders, dysregulation of the serotonergic system, a veryExpand
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N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking
  • A. Orr, S. Li, +7 authors X. Li
  • Biology, Medicine
  • The Journal of Neuroscience
  • 12 March 2008
Huntington's disease (HD) is caused by polyglutamine (polyQ) expansion in huntingtin (htt), a large (350 kDa) protein that localizes predominantly to the cytoplasm. Proteolytic cleavage of mutant httExpand
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Early Motor Dysfunction and Striosomal Distribution of Huntingtin Microaggregates in Huntington's Disease Knock-In Mice
Huntington's disease (HD) is characterized by a progressive loss of neurons in the striatum and cerebral cortex and is caused by a CAG repeat expansion in the gene encoding huntingtin. Mice with theExpand
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