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Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1
High-level immune activation and T cell apoptosis represent a hallmark of HIV-1 infection that is absent from nonpathogenic SIV infections in natural primate hosts. The mechanisms causing these… Expand
A novel wall-associated receptor-like protein kinase gene, OsWAK1, plays important roles in rice blast disease resistance
- H. Li, Shan-Yue Zhou, W. Zhao, Sheng-chang Su, Y. Peng
- Biology, Medicine
- Plant Molecular Biology
- 1 February 2009
Wall-associated protein kinases (WAKs) are a new group of receptor-like kinases (RLK) recently identified in Arabidopsis. A cDNA encoding a novel WAK was isolated from rice and was named OsWAK1… Expand
The use of reflective and permeable pavements as a potential practice for heat island mitigation and stormwater management
To help address the built environmental issues of both heat island and stormwater runoff, strategies that make pavements cooler and permeable have been investigated through measurements and modeling… Expand
Oxidative torrefaction of biomass residues and densification of torrefied sawdust to pellets.
- C. Wang, Jianghong Peng, +4 authors S. Sokhansanj
- Materials Science, Medicine
- Bioresource technology
Oxidative torrefaction of sawdust with a carrier gas containing 3-6% O(2) was investigated in a TG and a fluidized bed reactor, with the properties of the torrefied sawdust and pellets compared with… Expand
Effects of Cations and PH on Antimicrobial Activity of Thanatin and s-Thanatin against Escherichia coli ATCC25922 and B. subtilis ATCC 21332
Thanatin and s-thanatin were insect antimicrobial peptides which have shown potent antimicrobial activities on a variety of microbes. In order to investigate the effect of cations and pH on the… Expand
Characterisation of interaction between food colourant allura red AC and human serum albumin: multispectroscopic analyses and docking simulations.
Binding interaction of human serum albumin (HSA) with allura red AC, a food colourant, was investigated at the molecular level through fluorescence, ultraviolet-visible, circular dichroism (CD) and… Expand
Improvement strategy on enhanced biological phosphorus removal for municipal wastewater treatment plants: full-scale operating parameters, sludge activities, and microbial features.
The poor quality of effluent discharged by municipal wastewater treatment plants (WWTPs) is threatening the safety of water ecology. This study, which integrated a field survey, batch tests, and… Expand
Characteristics of 45° photonic crystal ring resonators based on square-lattice silicon rods
A new photonic crystal ring resonator (PCRR) configuration is provided based on two-dimensional (2D) square lattice photonic crystal (PC) silicon rods. The ring is formed by removing the line defect… Expand
MEMS-Based Microdevice for Cell Lysis and DNA Extraction
With the development of microelectromechanical system (MEMS) technology, micrototal analytical systems (┤TAS) which has the potential for integrating sample pretreatment, target amplification, and… Expand
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally…
- H. Li, J. Tatlock, +16 authors C. Lewis
- Chemistry, Medicine
- Journal of medicinal chemistry
- 11 February 2009
The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein, we report the optimization of the dihydropyrone series inhibitors to improve… Expand