Molecular Pathology of Human Haemoglobin
The haemoglobin molecule is insensitive to replacements of most amino-acid residues on its surface, but extremely sensitive to even quite small alterations of internal non-polar contacts, especially…
Haemoglobin gene frequencies in the Jamaican population: a study in 100,000 newborns
- G. Serjeant, B. Serjeant, M. Forbes, R. Hayes, D. Higgs, H. Lehmann
- MedicineBritish Journal of Haematology
- 1 October 1986
This survey represents a complete and accurate documentation of the α and β globin variants that occur in the Jamaican population and describes 256 rare abnormal haemoglobins.
Haemoglobin Titusville: alpha94 Asp replaced by Asn. A new haemoglobin with a lowered affinity for oxygen.
A new haemoglobin variant with a decreased oxygen affinity is described, in which the substitution, alpha 94 (G1) Asp replaced by Asn, affects the alpha1beta2 contact alpha1G1-beta2G4. The relevance…
On the evolution of myoglobin.
- A. E. Romero-Herrera, H. Lehmann, K. Joysey, A. Friday
- BiologyPhilosophical transactions of the Royal Society…
- 9 May 1978
Estimates of the rate of molecular evolution are of interest because its supposed constancy has been a major argument in favour of the hypothesis that a high proportion of fixed mutations are neutral, or nearly so, as far as selection is concerned.
The first observation of Hb D Punjab beta zero thalassaemia in an English family with 22 cases of unsuspected beta zero thalassaemia minor among its members.
A 36 year old local Englishman from Nuneaton was referred to hospital with suspected glandular fever and the finding of a hypochromic microcytic blood picture without iron deficiency led to the discovery that he was heterozygous for Hb D and beta thalassaemia.
The unstable haemoglobin haemolytic anaemias.
Different types of alpha-thalassaemia and significance of haemoglobin Bart's in neonates.
- H. Lehmann
- Biology, MedicineThe Lancet
- 11 July 1970
Molecular pathology of human haemoglobin.
Variations in the structure of human haemoglobin. With particular reference to the unstable haemoglobins.
α‐Thalassaemia as a Cause of Hydrops Foetalis
It is proposed that in certain arcas of the world, faulty haemoglobin production in the foetus may turn out to be a more important cause of erythroblastosis and hydrops leading to death than incompatibility between foctal aiid maternal blood.