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The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity
TLDR
It is shown that the 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. Expand
Male reproductive health and environmental xenoestrogens.
TLDR
The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active environmental chemicals during fetal and childhood development. Expand
Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours
TLDR
The protein expression of NANOG is analysed during normal development of human testis and in a large series of neoplastic/dysgenetic specimens to study self‐renewal and pluripotency in ESCs. Expand
Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin.
TLDR
Psoriasin was not detected in normal human fibroblasts, lymphocytes, endothelial cells and transformed epithelial cells of keratinocyte origin, suggesting that its overexpression by psoriatic keratinocytes may be linked to the inflammatory stimuli. Expand
Emerging endocrine disrupters: perfluoroalkylated substances.
TLDR
The acute toxicity of the polyfluorinated substances is moderate but some substances can induce peroxisome proliferation in rat livers and may change the fluidity of cell membranes, and hundreds of related chemicals, which potentially may degrade to perfluoroalkanoic (carboxylic) acids, are not regulated. Expand
Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.
TLDR
There was an association between the timing and the duration of mild analgesic use during pregnancy and the risk of cryptorchidism, and these findings were supported by anti-androgenic effects in rat models leading to impaired masculinization. Expand
Do Perfluoroalkyl Compounds Impair Human Semen Quality?
TLDR
High PFAA levels were associated with fewer normal sperm, which may contribute to the otherwise unexplained low semen quality often seen in young men, and these findings need to be corroborated in larger studies. Expand
A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation
TLDR
The association of single-nucleotide polymorphisms in the TGFBR3 and BMP7 genes, which belong to the transforming growth factor β signalling pathway, suggests a role for this pathway in the pathogenesis of TDS. Expand
Archaebacterial DNA-dependent RNA polymerases testify to the evolution of the eukaryotic nuclear genome.
TLDR
Unrooted phylogenetic dendrograms derived from both distance matrix and parsimony analyses show the archaebacteria are a coherent group closely related to the eukaryotic nuclear RNA polymerase II and/or III lineages. Expand
Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte.
TLDR
New evidence is provided that the molecular phenotype of CIS cells is similar to that of gonocytes, and it is speculated that disturbed development of somatic cells in the fetal testis may play a role in allowing undifferentiated cells to survive in the postnatal testes. Expand
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