Assessment of visceral pain-related pseudo-affective responses to colorectal distension in mice by intracolonic manometric recordings.
Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats.
Inhibition of gastric acid secretion by omeprazole in the dog and rat.
Evaluation of pseudo-affective responses to noxious colorectal distension in rats by manometric recordings
Differentiation among inhibitory actions of omeprazole, cimetidine, and SCN- on gastric acid secretion.
- B. Wallmark, B. M. Jaresten, H. Larsson, B. Ryberg, A. Brändström, E. Fellenius
- Biology, ChemistryAmerican Journal of Physiology
- 1 July 1983
Results obtained from intact mucosa and isolated glands are in agreement with the ability of omeprazole to inhibit the isolated H+-K+-ATPase and provide evidence of a novel mechanism of action for this inhibitor.
CB1 Receptors Mediate the Analgesic Effects of Cannabinoids on Colorectal Distension-Induced Visceral Pain in Rodents
- M. Brusberg, S. Arvidsson, Daiwu Kang, H. Larsson, E. Lindström, V. Martínez
- BiologyJournal of Neuroscience
- 4 February 2009
Data indicate that peripheral CB1 receptors mediate the analgesic effects of cannabinoids on visceral pain from the gastrointestinal tract, and suggest the existence of an endogenous cannabinoid tone and the activation of CB 1 receptors during noxious CRD.
Effects of pregabalin on visceral pain responses and colonic compliance in rats
- A. Ravnefjord, M. Brusberg, H. Larsson, E. Lindström, V. Martínez
- Medicine, BiologyBritish Journal of Pharmacology
- 1 October 2008
Pregabalin, which binds to the α2‐δ subunit of voltage‐gated calcium channels, increased the threshold for pain during colorectal distension (CRD) in irritable bowel syndrome (IBS) patients. We…
Time-course of development and reversal of gastric endocrine cell hyperplasia after inhibition of acid secretion. Studies with omeprazole and ranitidine in intact and antrectomized rats.
Animal pharmacodynamics of omeprazole. A survey of its pharmacological properties in vivo.
- H. Larsson, H. Mattson, G. Sundell, E. Carlsson
- Medicine, BiologyScandinavian Journal of Gastroenterology…
Omprazole seems to be very specific in its gastric acid antisecretory and gastric protective actions since, apart from a decrease in the rate of gastric emptying found after very high oral doses in the rat, no other general pharmacological effects of omeprazole have been observed.
Local acid production and Helicobacter pylori: a unifying hypothesis of gastroduodenal disease.
It is proposed that the most important factor in the ecology of the H. pylori-infected stomach is local acid production, which determines the location and severity of inflammation and the clinical outcome of this bacterial infection.