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Plasma and muscle tocopherol contents during vitamin E therapy in arterial disease
SummaryPlasma tocopherol levels have been determined after single oral doses of two different tocopheryl acetate formulations. It was shown that a tablet preparation of D-α-tocopheryl acetate in a
Changes of blood viscosity in patients treated with 5-fluorouracil--a link to cardiotoxicity?
The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen.
Pharmacokinetics of propranolol
The pharmacokinetics of propranolol after the administration of 40, 80, and 120 mg p.o.v. was studied in nine healthy male volunteers and there was no evidence of either dose dependent disposition kinetics or an oral threshold dose.
Pharmacokinetics of femoxetine in man.
The pharmacokinetic parameters were not found to be dose dependent in the range investigated, but it was not possible to decide whether the bioavailability was dependent on the dose.
Studies of blood viscosity with a newly constructed rotational viscometer which operates via a desk top computer.
A newly constructed rotational Couette type viscometer is presented which operates via a commercially available desk top computer and a digital plotter and the influence of haematocrit on blood viscosity is shown.
Pharmacokinetics of bendroflumethiazide after low oral doses
The pharmacokinetics of bendroflumethiazide after oral administration of 1.25, 2.5, and 5.0 mg were studied in nine healthy male volunteers and the urinary sodium concentration was doubled after bendro FLM intake, but the urinary potassium concentration remained almost constant.
Reversal of increased whole blood and plasma viscosity after treatment of hypothyroidism in man.
It is concluded that in hypothyroidism there are changes in both plasma and erythrocytes that increase blood viscosity, with normalization upon treatment with l-thyroxine to euthyroidism.
Correlations between fatty acid composition of the erythrocyte membrane and blood rheology data.
The results indicate that palmitic acid may be favourable in the PC fraction and stearic acid (18:0) unfavourable with respect to the rheological properties of erythrocytes and insulin treatment did not significantly change red cell deformability or the fatty acid composition of the red cell membrane.