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Levofloxacin. Its use in infections of the respiratory tract, skin, soft tissues and urinary tract.
TLDR
Oral levofloxacin can be administered in a once-daily regimen as an alternative to other fluoroquinolones in the treatment of infections of the urinary tract, skin and soft tissues and appears to have improved activity against Streptococcus pneumoniae. Expand
Zolpidem. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential.
TLDR
While zolpidem aids sedation, and may reduce memory or psychomotor function within the first 2 hours after administration of single oral doses, its use as a surgical premedicant remains to be established. Expand
Glimepiride. A review of its use in the management of type 2 diabetes mellitus.
TLDR
Pooled clinical trial data suggest that glimepiride may have a lower incidence of hypoglycaemia than glibenclamide, particularly in the first month of treatment, and its possible tolerability advantages and use in combination with other oral antidiabetic drugs require further study. Expand
Azithromycin. A review of its use in paediatric infectious diseases.
TLDR
Azithromycin is an effective and well tolerated alternative to first-line agents in the treatment of respiratory tract, skin and soft tissue infections in children, offerring the convenience of a short, once-daily regimen. Expand
Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer.
TLDR
Mitoxantrone is an effective and better tolerated alternative to the anthracyclines in most haematological malignancies, in breast cancer and in advanced hepatic or ovarian carcinoma, and synergy with other antineoplastic drugs has been demonstrated in murine tumour models. Expand
Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.
TLDR
Therapeutic trials involving several thousands of patients with peptic ulcer disease confirm that ranitidine 300mg daily administered orally in single or divided doses is at least as effective as cimetidine 800 to 1000mg daily in increasing the rate of healing of duodenal and gastric ulcers. Expand
Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.
TLDR
In acquired immunodeficiency syndrome and AIDS-related complex patients, orally and intravenously administered zidovudine is effective in reducing the incidence of opportunistic infections and neoplasms, increasing helper T lymphocyte numbers, and improving survival rates and quality of life. Expand
Topiramate. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of epilepsy.
TLDR
Preliminary reports support the use of add-on topiramate in adults with generalised epilepsy, in childhood epilepsies and in patients with Lennox-Gastaut syndrome, as well as theUse of topIRamate monotherapy in patientsWith refractory epilepsy,topiramate can be considered an important new drug for the management of patients with refractors. Expand
Clarithromycin. A review of its efficacy in the treatment of respiratory tract infections in immunocompetent patients.
TLDR
Clarithromycin provides similar clinical and bacteriological efficacy to that seen with beta-lactam agents, cephalosporins and other macrolides and is available in both once-daily and twice-daily formulations. Expand
Zopiclone. An update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia.
TLDR
Although the available data on rebound insomnia and dependence liability are encouraging, potential differences between zopiclone and the benzodiazepines in these respects may have little clinical relevance in the context of short term intermittent use of hypnotics, as it currently recommended. Expand
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