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Alginate as a chondrocyte-delivery substance in combination with a non-woven scaffold for cartilage tissue engineering.
- W. Marijnissen, G. V. van Osch, +4 authors J. Verhaar
- Materials Science, Medicine
- 1 March 2002
The use of alginate to seed chondrocytes in E210 does not influence the amount of cartilage matrix proteins produced per tissue wet weight, however, it provides retention of the graft shape. Expand
In vitro redifferentiation of culture-expanded rabbit and human auricular chondrocytes for cartilage reconstruction.
- G. V. van Osch, S. W. van der Veen, H. L. Verwoerd-Verhoef
- Plastic and reconstructive surgery
- 1 February 2001
This study demonstrates a method to regain cartilage phenotype in multiplied ear cartilage cells that improves the chances of generating human cartilage grafts for the reconstruction of external ears or the repair of defects of the nasal septum. Expand
Chondrogenic potential of in vitro multiplied rabbit perichondrium cells cultured in alginate beads in defined medium.
- G. V. van Osch, S. W. van der Veen, E. Burger, H. L. Verwoerd-Verhoef
- Biology, Medicine
- Tissue engineering
- 1 August 2000
It is demonstrated that more than 1 million cells can be generated out of 1 cm(2) of perichondrium tissue in 3-5 weeks of culture, irrespective of age, and that young auricular perichONDrium seems a useful source of cells for tissue engineering of cartilage when cultured in serum-free medium in combination with IG-F1 and TGF-beta2. Expand
The Potency of Culture-Expanded Nasal Septum Chondrocytes for Tissue Engineering of Cartilage
- G. V. van Osch, W. Marijnissen, S. W. van der Veen, H. L. Verwoerd-Verhoef
- American journal of rhinology
- 1 May 2001
This study demonstrates a method to regain cartilage phenotype in multiplied cells of nasal septum cartilage needed for tissue engineering of new cartilage. Expand
Effect of transforming growth factor-beta on proteoglycan synthesis by chondrocytes in relation to differentiation stage and the presence of pericellular matrix.
- G. V. van Osch, S. W. van der Veen, P. Buma, H. L. Verwoerd-Verhoef
- Chemistry, Medicine
- Matrix biology : journal of the International…
- 1 October 1998
The results indicate that, in pathological cartilage, matrix depletion might be the trigger for increased matrix synthesis in reaction to TGF-beta, suggesting an important role for TGF -beta in cartilage repair. Expand
Rhinosurgery in children: developmental and surgical aspects of the growing nose
- C. Verwoerd, H. L. Verwoerd-Verhoef
- GMS current topics in otorhinolaryngology, head…
- 12 April 2010
A list of guidelines to be considered before starting to perform surgery on the growing midface in children is compiled, based on their observations in animals and a few clinical studies, mostly with small numbers of patients but with a long follow-up. Expand
Rhinosurgery in children: basic concepts.
The essential problem in pediatric rhinosurgery is not the age-specific anatomy but the poor wound-healing capacity: fractured or transected septum cartilage will not heal, and disconnected ends tend to overlap, resulting in increasing or recurrent deviations. Expand
The dual role of perichondrium in cartilage wound healing.
- M. Duynstee, H. L. Verwoerd-Verhoef, C. Verwoerd, G. V. van Osch
- Plastic and reconstructive surgery
- 15 September 2002
The results of this experimental in vitro study demonstrate the dual role of perichondrium in cartilage wound healing, on the one hand, the inner layer of the perichONDrium, adjacent to the cartilage, provides (in time) cells for new cartilage formation, while the outer layer rapidly produces fibrous overgrowth, preventing the good cartilage-to-cartilage connection necessary to restore the mechanical function of the structure. Expand
A morphometric study of the growth of the subglottis after endolaryngeal trauma.
- F. Adriaansen, H. L. Verwoerd-Verhoef, R. O. van der Heul, C. Verwoerd
- International journal of pediatric…
- 1 December 1986
In young rabbits the growth of the subglottis was studied over a period of 20 weeks following an endolaryngeal trauma, and a stenosis in the adult stage appeared to be caused by a specific change in the pattern of growth leading up to an anterior narrowing of the cricoid ring and a conspicuous thickening of theSubepithelial layer. Expand
Intrinsic and extrinsic factors relevant to the morphology of the growing cricoid ring after a combined anterior and posterior cricoid split: an experimental study in rabbits.
The effects of a Rethi procedure upon the cricoid is investigated in young rabbits and it is demonstrated to result in an enlarged cricoids lumen in the adult stage due to an enhancement of both the anterior and posterior transversal diameter of the ring. Expand