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Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways.
The current interest in expression of groups of functionally related genes creates a demand for novel experimental tools. We describe a multiplex ligation-dependent amplification procedure (RT-MLPA),Expand
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Hedgehog signaling maintains chemoresistance in myeloid leukemic cells
The development of resistance against chemotherapy remains one of the major challenges in the clinical management of leukemia. There is still limited insight into the molecular mechanisms thatExpand
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Activated protein C protects against myocardial ischemia/ reperfusion injury via inhibition of apoptosis and inflammation.
OBJECTIVE In spite of major advances in reperfusion therapy for patients presenting with acute coronary syndrome, long-term morbidity is still substantial. A limitation of initial treatment ofExpand
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Protease-activated receptor-1 drives pancreatic cancer progression and chemoresistance.
Protease activated receptor (PAR)-1 expression in tumor cells is associated with disease progression and overall survival in a variety of cancers of epithelial origin; however, the importance ofExpand
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Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice.
BACKGROUND Inhibition of specific coagulation pathways such as the factor VIIa-tissue factor complex has been shown to attenuate ischemia/reperfusion (I/R) injury, but the cellular mechanisms haveExpand
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Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis
Tissue factor (TF) is traditionally known as the initiator of blood coagulation, but TF also plays an Important role In inflammatory processes. Considering the pivotal role of coagulation inExpand
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Expression pro®ling via novel multiplex assay allows rapid assessment of gene regulation in de®ned signalling pathways
The current interest in expression of groups of functionally related genes creates a demand for novel experimental tools. We describe a multiplex ligation-dependent ampli®cation procedure (RT-MLPA),Expand
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CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells.
CCAAT/enhancer-binding protein δ (C/EBPδ) is a transcription factor involved in growth arrest and differentiation, which has consequently been suggested to harbor tumor suppressive activities.Expand
Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation
Targeting tumor-infiltrating macrophages limits progression and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma (PDAC). Protease-activated receptor (PAR)1 drivesExpand