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Drug interactions at GABAA receptors
Neurotransmitter receptor systems have been the focus of intensive pharmacological research for more than 20 years for basic and applied scientific reasons, but only recently has there been a betterExpand
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The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes.
The amino acid gamma-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotransmitter that mediates most of its effects through fast GABA-gated Cl(-)-channels (GABAAR). MolecularExpand
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A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.
Benzodiazepines (BZ) modulate neurotransmitter-evoked chloride currents at the gamma-aminobutyric acid type A (GABAA) receptor, the major inhibitory ion channel in the mammalian brain. This receptorExpand
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NMDA receptor channels: Subunit-specific potentiation by reducing agents
Sulfhydryl redox agents affect NMDA receptor activity. We investigated a putative redox site in four recombinant NMDA receptors. In 293 cells expressing NR1-NR2A channels dithiothreitol (DTT) rapidlyExpand
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Drug interactions at GABA(A) receptors.
Neurotransmitter receptor systems have been the focus of intensive pharmacological research for more than 20 years for basic and applied scientific reasons, but only recently has there been a betterExpand
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GABAA/Benzodiazepine receptor heterogeneity: Neurophysiological implications
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Type I and type II GABAA-benzodiazepine receptors produced in transfected cells.
GABAA (gamma-aminobutyric acid A)-benzodiazepine receptors expressed in mammalian cells and assembled from one of three different alpha subunit variants (alpha 1, alpha 2, or alpha 3) in combinationExpand
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Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor.
Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can beExpand
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Cerebellar GABAA receptor selective for a behavioural alcohol antagonist
BENZODIAZEPINES are widely prescribed anxiolytics and anti-convulsants which bind with high affinity to sites on the GABAA receptor/Cl– channel complex and potentiate the effect of theExpand
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Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor α4 subunit
A cDNA of rat brain encoding the GABAA receptor α4 subunit has been cloned. Recombinant receptors composed of α4, β2 and γ2 subunits bind with high affinity the GABA agonist [3H]muscimol and theExpand
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