Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora".
- H. Kwon, C. Kauffman, P. Jensen, W. Fenical
- Chemistry, BiologyJournal of the American Chemical Society
- 13 January 2006
Marinomycins A-D show significant antimicrobial activities against drug resistant bacterial pathogens and demonstrate impressive and selective cancer cell cytotoxicities against six of the eight melanoma cell lines in the National Cancer Institute's 60 cell line panel.
Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/Bcl(XL)-regulated mitochondrial apoptotic pathway.
- Kewu Zeng, Xue-mei Wang, Hyeonseok Ko, H. Kwon, J. Cha, Hyun-Ok Yang
- Biology, ChemistryEuropean Journal of Pharmacology
- 15 December 2011
Sungsanpin, a lasso peptide from a deep-sea streptomycete.
- S. Um, Young-Joo Kim, D. Oh
- ChemistryJournal of Natural Products
- 10 May 2013
Sungsanpin is the first example of a lasso peptide isolated from a marine-derived microorganism and displayed inhibitory activity in a cell invasion assay with the human lung cancer cell line A549.
Sphingolipids from Bombycis Corpus 101A and their neurotrophic effects.
- H. Kwon, Kang Choon Lee, K. Lee
- ChemistryJournal of Natural Products
- 20 March 2003
Three new (2) and one known (1) sphingolipid were identified in the MeOH extract of Bombycis Corpus 101A and their neurotrophic effects were evaluated by examining PC12 cell neurite outgrowth.
Anti-cancer Effect of Luminacin, a Marine Microbial Extract, in Head and Neck Squamous Cell Carcinoma Progression via Autophagic Cell Death
- Y. S. Shin, Hyun-Young Cha, E. Choi
- Biology, MedicineCancer research and treatment : official journal…
- 9 September 2015
It is demonstrated that luminacin induces the inhibition of growth and cancer progression via autophagic cell death in HNSCC cell lines, indicating a possible alternative chemotherapeutic approach for treatment of H NSCC.
Marinomycins A—D, Antitumor‐Antibiotics of a New Structure Class from a Marine Actinomycete of the Recently Discovered Genus “Marinispora”.
- H. Kwon, C. Kauffman, P. Jensen, W. Fenical
- Biology
- 13 June 2006
Glionitrin A, an antibiotic-antitumor metabolite derived from competitive interaction between abandoned mine microbes.
- Hyun Bong Park, H. Kwon, Chang-Ho Lee, Hyun-Ok Yang
- BiologyJournal of Natural Products
- 21 January 2009
The nutrient conditions present in abandoned coal mine drainages create an extreme environment where defensive and offensive microbial interactions could be critical for survival and fitness.…
Glionitrin B, a cancer invasion inhibitory diketopiperazine produced by microbial coculture.
- Hyun Bong Park, Young-Joo Kim, Jin-Soo Park, Hyun-Ok Yang, K. Lee, H. Kwon
- Chemistry, BiologyJournal of Natural Products
- 28 September 2011
A new diketopiperazine, glionitrin B (1), was produced using a microbial coculture of the fungus Aspergillus fumigatus KMC-901 and the bacterium Sphingomonas sp. KMK-001 that were isolated from…
Apoptosis‐inducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines
- E. J. Choi, J. Park, H.O. Yang
- Biology, ChemistryJournal of Applied Microbiology
- 1 January 2011
Aims: Research is to identify the bioactive secondary metabolites produced by Aspergillus sp. KMD 901 isolated from marine sediment and to assess their apoptosis‐inducing effects.
New cytotoxic butanolides from Lindera obtusiloba BLUME.
- H. Kwon, N. Baek, S. U. Choi, K. R. Lee
- ChemistryChemical and pharmaceutical bulletin
- 1 May 2000
Three new butanolides were isolated from the stems of Lindera obtusiloba BLUME and exhibited cytotoxicity against cultured human tumor cell lines with their ED50 values ranging from 3.19 to 14.63 microg/ml.
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