• Publications
  • Influence
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
TLDR
It is shown that beta-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance, and Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system.
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
TLDR
It is shown that the loss of Smoothened (Smo), an essential component of the Hh pathway, impairs haematopoietic stem cell renewal and decreases induction of chronic myelogenous leukaemia (CML) by the BCR–ABL1 oncoprotein.
Regulation of myeloid leukemia by the cell fate determinant Musashi
TLDR
The data show that the Musashi–Numb pathway can control the differentiation of CML cells, and raise the possibility that targeting this pathway may provide a new strategy for the therapy of aggressive leukaemias.
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
TLDR
This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance”, which is a type of “plague” found in the immune system.
Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment
TLDR
This review highlights the key features and mechanisms that regulate CSC function in drug resistance as well as recent breakthroughs of therapeutic approaches for targeting CSCs and provides better therapeutic rationales to accompany novel anticancer therapeutics.
Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
TLDR
It is shown that the dynein-binding protein Lis1 is critically required for hematopoietic stem cell function and leukemogenesis, and deletion of Lis1 blocked the propagation of myeloid leukemia and led to a marked improvement in survival.
Effect of Heat Shock and Mutations in ClpL and ClpP on Virulence Gene Expression in Streptococcus pneumoniae
TLDR
Interestingly, immunoblot and real-time reverse transcription-PCR analysis demonstrated that pneumolysin and pneumococcal surface antigen A were induced by heat shock in wild-type S. pneumoniae.
Melatonin and 5‐fluorouracil co‐suppress colon cancer stem cells by regulating cellular prion protein‐Oct4 axis
TLDR
This study found that melatonin inhibits colon CSCs by regulating the PrPC‐Oct4 axis, and suggests that co‐treatment with anticancer drug and melatonin is a potential therapy for colorectal cancer.
...
...