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Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
There has been a marked increase in the incidence of autoimmune diseases in the past half-century. Although the underlying genetic basis of this class of diseases has recently been elucidated,… Expand
Prorenin and Renin-Induced Extracellular Signal–Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide
The recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by activating mitogen-activated protein kinases and promotes nonproteolytic prorenin activation. In vivo,… Expand
Interferon-&ggr; Signaling Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage
Angiotensin (Ang) II induces vascular injury in part by activating innate and adaptive immunity; however, the mechanisms are unclear. We investigated the role of interferon (IFN)-&ggr; and… Expand
Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage
Background— Hypertensive target organ damage, especially cardiac hypertrophy with heart failure and arrhythmia, is a major source of morbidity and mortality. Angiotensin II, a major mediator of… Expand
Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system
- J. Stegbauer, Da-Hye Lee, +8 authors R. Linker
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 1 September 2009
Angiotensin II is the principle effector molecule of the renin angiotensin system (RAS). It exerts its various actions on the cardiovascular and renal system, mainly via interaction with the… Expand
Immune-related effects in hypertension and target-organ damage
Purpose of reviewSeveral studies published in the past three decades have suggested that inflammation and activation of immunity are central features in the pathogenesis of atherosclerosis, ischemic… Expand
Vitamin D review
- D. Müller, M. Kleinewietfeld, H. Kvakan
- Journal of the renin-angiotensin-aldosterone…
- 1 June 2011
Dominik N Muller1,2, Markus Kleinewietfeld3 and Heda Kvakan2,4 1 Nikolaus-Fiebiger-Centre for Molecular Medicine, Friedrich-Alexander-University, Erlangen-Nurnberg, Germany 2 Max-Delbruck Center for… Expand
Differential effect of ischaemic preconditioning on mobilisation and recruitment of haematopoietic and mesenchymal stem cells in porcine myocardial ischaemia-reperfusion.
Effects of ischaemic preconditioning (IP) on the mobilisation and recruitment of haematopoietic (HSCs) and mesenchymal stem (MSC) cells were determined in porcine coronary occlusion/reperfusion.… Expand
Fractalkine receptor polymorphisms V2491 and T280M as genetic risk factors for restenosis.
The chemokine fractalkine (FKN) recruits leukocytes into lesions of the arterial wall, which may lead to restenosis after stenting. FKN also regulates proliferation of smooth muscle cells, another… Expand
Role of the immune system in hypertensive target organ damage.
Recent advances in our understanding of cardiovascular diseases clearly show that inflammation and activation of immunity are central features in the pathogenesis of atherosclerosis, ischemic… Expand