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Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer
TLDR
Exons 18–21 of the tyrosine kinase domain of the epidermal growth factor receptor(EGFR) gene define a distinct subset of pulmonary adenocarcinoma without KRAS mutations, which is not caused by tobacco carcinogens. Expand
Analysis of Epidermal Growth Factor Receptor Gene Mutation in Patients with Non–Small Cell Lung Cancer and Acquired Resistance to Gefitinib
TLDR
A secondary T790M mutation of EGFR accounted for half the tumors with acquired resistance to gefitinib in Japanese patients, and other drug-resistant secondary mutations are uncommon in the EGFR gene. Expand
Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society
TLDR
These guidelines are intended for doctors who are engaged in the diagnosis and treatment of esophageal carcinoma to present the standard practice with a high regard for the principles of evidence-based medicine (EBM), and to improve the safety and results of treatment. Expand
Gum chewing enhances early recovery from postoperative ileus after laparoscopic colectomy.
TLDR
Gum chewing aids early recovery from postoperative ileus and is an inexpensive and physiologic method for stimulating bowel motility. Expand
E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma
TLDR
Cadherin switch promotes cancer progression via TGF-β-induced EMT inextrahepatic CC, suggesting a target for elucidating the mechanisms of invasion and metastasis in extrahepatics CC. Expand
A comparative study of the anatomy of rat and human livers.
TLDR
The fundamental structures of rat and human livers were similar, and the findings demonstrated a new interpretation of the anatomy of the human liver. Expand
Evaluation of 18F-2-deoxy-2-fluoro-d-glucose Positron Emission Tomography for Gastric Cancer
TLDR
FDG-PET appears to provide important additional information concerning the aggressiveness of the tumor and the prognosis in patients with gastric cancer. Expand
Prognostic Implication of EGFR, KRAS, and TP53 Gene Mutations in a Large Cohort of Japanese Patients with Surgically Treated Lung Adenocarcinoma
TLDR
EGFR, KRAS, and TP53 gene mutations were not independently associated with the prognosis for Japanese patients with surgically treated lung adenocarcinoma. Expand
The Diagnosis and Treatment of Adult Intussusception
TLDR
The CT scan is most useful in making the diagnosis of intussusception and small bowel lesions should be reduced only in patients in whom a benign diagnosis has been strongly suggested preoperatively or in Patients in whom resection may result in short gut syndrome. Expand
Activation of MET by Gene Amplification or by Splice Mutations Deleting the Juxtamembrane Domain in Primary Resected Lung Cancers
TLDR
About 5% of pulmonary adenocarcinomas in this cohort of Japanese patients were driven by activated MET by gene amplification or splice mutations, which would be candidates for targeted therapy against MET. Expand
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