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High catalytic activity of human cytochrome P450 co-expressed with human NADPH-cytochrome P450 reductase in Escherichia coli.
TLDR
When co-expressed with the reductase, human P450 catalyzed the oxidation of representative substrates at efficient rates comparable to the reported activities of P 450 in a reconstituted system containing purified preparations of P450 and the reduCTase. Expand
Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase.
TLDR
It is concluded that human CYP2E1 is mainly responsible for the metabolic activation of N-nitrosamines with a relatively short alkyl chain(s), whereas CyP2A6 was predominantly responsible forThe metabolic activation for N-alkylnitrosamine possessing a relatively bulky alkyL chain. Expand
The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan
TLDR
In vitro and in vivo BBB permeability data suggest that target ingredient GM in yokukansan administered orally is absorbed into the blood and then reaches the brain through the BBB, which further supports the possibility that GM is an active component in the psychotropic effect of yokUKansan. Expand
Genetic polymorphism of CYP2A6 in relation to cancer.
TLDR
The whole deletion of CYP2A6 gene as a type of genetic polymorphism in Japanese is found and a gene diagnosis method to detect the variant is developed and evaluated the relationship between the CYP1A7 gene whole deletion and the susceptibility to the lung cancer. Expand
Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines.
TLDR
Results indicate that the intracellular expression of drug-metabolizing enzymes makes the established strain of Salmonella highly sensitive to mutagenic HCAs. Expand
Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108.
TLDR
A new Salmonella tester strain highly sensitive to promutagenic N-nitrosamines is developed by introducing a plasmid carrying human CYP2A6 and NADPH-cytochrome P450 reductase (OR) cDNA into the ada- and ogt-deficient strain YG7108, and it is believed that this is the first demonstration that CYP 2A6 is responsible for the metabolic activation of NMPhA. Expand
Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using
TLDR
A sensitive and specific high-performance liquid chromatography with tandem mass spectrometry (LC/MS/MS) method for the simultaneous quantitation of seven UH alkaloids in rat plasma and brain suggests that geissoschizine methyl ether is an important constituent of the pharmacological effects of Yokukansan. Expand
Ginsenosides, ingredients of the root of Panax ginseng, are not substrates but inhibitors of sodium-glucose transporter 1
TLDR
Whether ginsenosides Rb1 and Rg1, and their metabolites from enteric bacteria act as substrates of sodium-glucose cotransporter (SGLT) 1, the major glucose transporter expressed on the apical side of intestinal epithelial cells, is evaluated. Expand
Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocylic amines.
TLDR
It is suggested that the intracellular expression of drug-metabolising enzymes makes the Salmonella cells highly sensitive to the HCAs. Expand
The influence of the sennosides on absorption of glycyrrhetic acid in rats.
TLDR
The decrease of the pharmacokinetic parameters of GA in human plasma observed in the clinical study of TJ-8117 is attributable to an interactive action of absorption from the intestinal tract by anthraquinones contained in or derived from rhubarb. Expand
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