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Role of the Streptococcus mutans gtf genes in caries induction in the specific-pathogen-free rat model
- Y. Yamashita, W. Bowen, R. Burne, H. Kuramitsu
- Biology, MedicineInfection and immunity
- 1 September 1993
The role of each of the Streptococcus mutans gtf genes coding for glucan synthesis in cariogenesis was evaluated by using strain UA130 in the specific-pathogen-free (SPF) rat model system, and results suggest that all four genes are important for smooth-surface caries formation.
Cloning of a Streptococcus mutans glucosyltransferase gene coding for insoluble glucan synthesis
- H. Aoki, T. Shiroza, M. Hayakawa, S. Sato, H. Kuramitsu
- Biology, MedicineInfection and immunity
- 1 September 1986
Results indicate that the gtfB gene codes for a GTF involved in insoluble glucan synthesis in strain GS-5, and evidence for the existence of a distinct gene sharing partial homology with gTFB was obtained.
Interactions between Periodontal Bacteria and Human Oral Epithelial Cells: Fusobacterium nucleatum Adheres to and Invades Epithelial Cells
- Yiping W. Han, Wenyuan Shi, +4 authors R. Genco
- Biology, MedicineInfection and Immunity
- 1 June 2000
An initial demonstration that F. nucleatum adhered to and invaded HGEC and that this was accompanied by high levels of IL-8 secretion from the epithelial cells is provided, indicating the requirement of bacterial components in these processes.
Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes.
- S. Gottesman, C. Squires, +7 authors T. Foster
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 May 1990
The high degree of similarity among the ClpA-like proteins suggests that Clp-like proteases are likely to be important participants in energy-dependent proteolysis in prokaryotic and eukaryotic cells.
Interspecies Interactions within Oral Microbial Communities
- H. Kuramitsu, Xuesong He, R. Lux, Maxwell H. Anderson, W. Shi
- Medicine, BiologyMicrobiology and Molecular Biology Reviews
- 1 December 2007
This review describes some of the interesting interspecies-interaction scenarios in oral microbial communities, which indicate that the whole is much more than the simple sum of its parts, since the interactions between different parts resulted in many new physiological functions which cannot be observed with individual components.
LuxS-Based Signaling Affects Streptococcus mutans Biofilm Formation
- A. Yoshida, T. Ansai, T. Takehara, H. Kuramitsu
- Biology, MedicineApplied and Environmental Microbiology
- 1 May 2005
Results suggest that the regulation of the glucosyltransferase genes required for sucrose-dependent biofilm formation is regulated by autoinducer-2, and provide further confirmation of previous proposals that quorum sensing via AI-2 may play a significant role in oral biofilms formation.
Virulence factors of mutans streptococci: role of molecular genetics.
- H. Kuramitsu
- Biology, MedicineCritical reviews in oral biology and medicine…
The introduction of molecular genetic approaches for characterizing these factors has led not only to a clearer understanding of the role of these virulence factors in cariogenicity but has also suggested some novel approaches for reducing further the incidence of dental caries.
Genetic Analysis of a Unique Bacteriocin, Smb, Produced by Streptococcus mutans GS5
It is demonstrated that Smb expression is induced by the competence-stimulating peptide (CSP) and that a com box-like sequence is located in the smb promoter region, suggesting that SMB belongs to the class I bacteriocin family, and its expression is dependent on CSP-induced quorum sensing.
Multiple Streptococcus mutans Genes Are Involved in Biofilm Formation
Results suggest that competence genes as well as the sgp and dgk genes may play important roles in S. mutans biofilm formation.
Interleukin-8 and Intercellular Adhesion Molecule 1 Regulation in Oral Epithelial Cells by Selected Periodontal Bacteria: Multiple Effects of Porphyromonas gingivalis via Antagonistic Mechanisms
- G. T. Huang, Daniela Kim, Jonathan K.-H. Lee, H. Kuramitsu, S. Haake
- Medicine, BiologyInfection and Immunity
- 1 March 2001
Results suggested that IL-8 attenuation at the protein level might be associated with P. gingivalis proteases, but this effect was overridden when the bacteria were continuously cocultured with the epithelial cells.