• Publications
  • Influence
GENERAL INTRODUCTION
  • H. Kunkel
  • Psychology
    The Journal of experimental medicine
  • 1 September 1971
TLDR
This research aims to establish a causative mechanism behindGray matter damage in multiple sclerosis and its impact on clinical symptoms and aims to describe this process in more detail.
Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus.
Sera of patients with systemic lupus erythematosus were demonstrated to contain precipitating antibodies to soluble tissue components other than DNA. One dominant reaction was observed which was
Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells
TLDR
It was evident that the T blasts expressed similar HLA-DR determinants to those on B cells from the same donor; occasional minor differences between stimulated T cells and autologous B-cell lines or fresh B cells were encountered.
Individual Antigenic Specificity of Isolated Antibodies
TLDR
Antisera produced against certain isolated human antibodies showed clear antigenic differences between these antibodies, and failure to produce specific antisera in other instances appeared to be correlated with a greater heterogeneity of the antibody population used as antigen.
IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS OF SYSTEMIC LUPUS ERYTHEMATOSUS
TLDR
The immunochemical evidence for the high specific activity of antinuclear antibodies and the association of DNA antigen with DNA antibody in glomeruli add further support for the antigen-antibody complex hypothesis for renal injury in systemic lupus erythematosus.
Isolation of a Thermolabile Serum Protein which Precipitates γ-Globulin Aggregates and Participates in Immune Hemolysis.∗
TLDR
A protein of normal human serum capable of precipitating soluble aggregates of γ-globulin was isolated and found to be a euglobulin with an S° 20.w = 11 S and the approximate electrophoretic mobility ofγ- globulin, which proved thermolabile and independent of Ca++ and Mg++.
Alterations of estrogen metabolism in systemic lupus erythematosus.
TLDR
Patients with SLE have abnormal patterns of estradiol metabolism, leading to increased estrogenic activity, according to measurement of urinary metabolites after injection of labeled 3H-estradiol.
Deoxyribonucleic Acid ( DNA ) and Antibodies to DNA in the Serum of Patients with Systemic Lupus Erythematosus *
TLDR
It has been suggested that in addition to the immunological reactions observed in the skin lesions by the fluorescent anti-body technique, certain soluble tissue antigens may be released into the circulation during tissue injury and combine with specific antibody to form immunological complexes resulting in damage to other organs as well.
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