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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon inducers, we have identified here a molecule we call interferon-β promoter… Expand
Pathogen Recognition by the Innate Immune System
Microbial infection initiates complex interactions between the pathogen and the host. Pathogens express several signature molecules, known as pathogen-associated molecular patterns (PAMPs), which are… Expand
Pathogen recognition in the innate immune response.
Immunity against microbial pathogens primarily depends on the recognition of pathogen components by innate receptors expressed on immune and non-immune cells. Innate receptors are evolutionarily… Expand
Toll-like receptors and innate immunity.
Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in various immune and non-immune cells of the mammalian host. TLRs play a crucial role in defending against… Expand
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Successful vaccines contain not only protective antigen(s) but also an adjuvant component that triggers innate immune activation and is necessary for their optimal immunogenicity. In the case of DNA… Expand
Essential role of IPS-1 in innate immune responses against RNA viruses
- H. Kumar, T. Kawai, +8 authors S. Akira
- Biology, Medicine
- The Journal of experimental medicine
- 10 July 2006
IFN-β promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (Mda5), which recognize distinct RNA… Expand
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Type I interferons (IFNs) are critical for antiviral responses. Here we generated a knockin mouse in which green fluorescence protein (GFP) was expressed under the control of the Ifna6 promoter.… Expand
The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.
The innate immune system detects pathogen- and host-derived double-stranded DNA exposed to the cytosol and induces type I interferon (IFN) and other cytokines. Here, we identified… Expand
Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination
The innate immune system recognizes influenza A virus via TLR 7 or retinoic acid-inducible gene I in a cell-type specific manner in vitro, however, physiological function(s) of the MyD88- or… Expand
Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-Stranded RNA
- K. Takahashi, T. Kawai, H. Kumar, S. Sato, S. Yonehara, S. Akira
- Biology, Medicine
- The Journal of Immunology
- 15 April 2006
Upon viral infection, host cells trigger antiviral immune responses by inducing type I IFN and inflammatory cytokines. dsRNA generated during viral replication is recognized by the cytoplasmic RNA… Expand