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Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis
It remains under dispute whether status epilepticus (SE) in the perinatal period or early childhood or the underlying neuropathology is the cause of functional impairment later in life. The presentExpand
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Selection of Antiepileptic Drug Polytherapy Based on Mechanisms of Action: The Evidence Reviewed
Summary: Purpose: When monotherapy with antiepileptic drugs (AEDs) fails, combination therapy is tried in an attempt to improve effectiveness by improving efficacy, tolerability, or both. We reviewedExpand
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Status Epilepticus Causes Necrotic Damage in the Mediodorsal Nucleus of the Thalamus in Immature Rats
Status epilepticus (StE) in immature rats causes long-term functional impairment. Whether this is associated with structural alterations remains controversial. The present study was designed to testExpand
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Long-term behavioral and morphological consequences of nonconvulsive status epilepticus in rats
The aims of the present study were to ascertain whether nonconvulsive status epilepticus (NCSE) could give rise to long-term behavioral deficits and permanent brain damage. Two months after NCSE wasExpand
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Pentylenetetrazol-induced seizures in rats: an ontogenetic study
SummaryA quantitative description of motor seizures induced by pentylenetetrazol (PTZ, metrazol) was performed. Seizures were induced by PTZ in doses from 40 to 120 mg/kg s.c. in 477 male albino ratsExpand
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Treatment of Experimental Status Epilepticus in Immature Rats: Dissociation Between Anticonvulsant and Antiepileptogenic Effects
We studied the effects of treating status epilepticus (SE) induced by lithium and pilocarpine at postnatal day 15 (P15) or 28 (P28), on the severity of acute SE and of SE-induced epileptogenesis.Expand
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Seizures Induced by Homocysteine in Rats During Ontogenesis
Summary: We studied the convulsant action of homocysteine in 211 immature and adult Wistar albino rats. Homocysteine elicited minimal, predominantly clonic, and major generalized tonic‐clonicExpand
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Maturation and segregation of brain networks that modify seizures
The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions whichExpand
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Action of Antiepileptic Drugs Against Kainic Acid‐Induced Seizures and Automatisms During Ontogenesis in Rats
Summary: Kainic acid (KA 4–14 mg/kg) administered intraperitoneally (i.p.) produces automatisms (scratching until third postnatal week, “wet dog” shakes thereafter), and clonic and tonic‐clonicExpand
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Five percent CO2 is a potent, fast‐acting inhalation anticonvulsant
Purpose:  CO2 has been long recognized for its anticonvulsant properties. We aimed to determine whether inhaling 5% CO2 can be used to suppress seizures in epilepsy patients. The effect of CO2 onExpand
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