H. Kubo

Publications269
h-index20
Citations1,502
Highly Influential Citations37
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Multiple Mechanisms Regulate Circadian Expression of the Gene for Cholesterol 7α-Hydroxylase (Cyp7a), a Key Enzyme in Hepatic Bile Acid Biosynthesis
Cholesterol 7α-hydroxylase (CYP7A) and sterol 12α-hydroxylase (CYP8B) in bile acid biosynthesis and 3-hydroxyl-3-methylglutaryl CoA reductase (HMGCR) in cholesterol biosynthesis are the key enzymes… Expand
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An adaptive maximum-likelihood sequence estimator for fast time-varying intersymbol interference channels
TLDR
This paper proposes an adaptive maximum-likelihood sequence estimator (MLSE), which is a suboptimum approximation to the adaptive maximum likelihood detector and is capable of tracking fast time-varying intersymbol interference (ISI) channels. Expand
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The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury
Inflammatory stimuli, such as a microbes or lipopolysaccharides, induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host… Expand
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Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice.
AIM The present study was conducted to define the relationship between the anti-aging effect of ubiquinol-10 supplementation and mitochondrial activation in senescence-accelerated mouse prone 1… Expand
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Opposite Effects of Wortmannin and 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one Hydrochloride on Toll-Like Receptor-Mediated Nitric Oxide Production: Negative Regulation of Nuclear Factor-κB by…
A number of previous studies have suggested the involvement of phosphoinositide 3-kinase (PI3K) in Toll-like receptor (TLR) signaling. However, there have also been a number of conflicting reports.… Expand
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Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress
Interleukin 17 (IL-17)–producing γδ T cells (γδ17 T cells) have been recently found to promote tumor growth and metastasis formation. How such γδ17 T-cell responses may be regulated in the tumor… Expand
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Kinematics and dynamics of a 6 degree-of-freedom fully parallel manipulator with elastic joints
Abstract This paper deals with the kinematics and dynamics analysis of a 6 degree-of-freedom RTS fully parallel manipulator with elastic joints. The elastic joints are used to realize highly precise… Expand
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Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema.
Hepatocyte growth factor (HGF) has multiple biological effects on stem cells, epithelial proliferation, and wound healing. In this study, we investigated a possible therapeutic benefit of intranasal… Expand
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Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition
Our recent studies revealed that supplementation with the reduced form of coenzyme Q10 (CoQ10H2) inhibits oxidative stress and slows the process of aging in senescence-accelerated mice. CoQ10H2… Expand
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Likelihood Estimation for Reduced-Complexity ML Detectors in a MIMO Spatial-Multiplexing System
TLDR
This paper proposes a likelihood estimation method for reduced-complexity maximum-likelihood (ML) detectors in a multiple-input multiple-output (MIMO) spatial-multiplexing (SM) system. Expand
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