Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
In vitro application of Hedgehog or P THrP protein to normal or PTHrP (−/−) limb explants demonstrated that PTHRP mediates the effects of Ihh through the formation of a negative feedback loop that modulates the rate of chondrocyte differentiation.
Osteoblastic cells regulate the haematopoietic stem cell niche
Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Developmental regulation of the growth plate
- H. Kronenberg
- 15 May 2003
The past few years have seen an enormous increase in understanding of the signalling pathways and the transcription factors that control endochondral bone development.
PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth
The results suggest that the PTH/P THrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation.
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.
Analysis of earlier developmental stages revealed that disturbance in cartilage growth preceded abnormal endochondral bone formation, and direct evidence implicating PTHrP in normal skeletal development is provided to emphasize its potential involvement in human osteochondrodysplasias.
Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation.
Maternal adaptive goals during pregnancy and during lactation, andfetal response to maternal hyper- or hypoparathy-roidism, and Integrated fetal calcium homeostasis, are studied.
Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.
A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.
Striking homology with the calcitonin receptor and lack of homological with other G protein-linked receptors indicate that receptors for these calcium-regulating hormones are related and represent a new family.
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
A model wherein Notch signaling in bone marrow normally acts to maintain a pool of mesenchymal progenitors by suppressing osteoblast differentiation is supported, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway.
Genetic control of bone formation.
- G. Karsenty, H. Kronenberg, C. Settembre
- MedicineAnnual Review of Cell and Developmental Biology
- 6 October 2009
This review aims to present a comprehensive view of the current state of knowledge in the field of chondrogenesis and osteoblastogenesis, which will also cover the most salient aspects of osteoplast function.