Share This Author
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
The different catalytic properties and the different subnuclear localization patterns shown by the human homologues indicate that hABH2 and hABh3 have distinct roles in the cellular response to alkylation damage, which is important for establishing RNA repair as a potentially important defence mechanism in living cells.
DNA glycosylases in the base excision repair of DNA.
Structural data and sequence comparisons have identified common features among many of the DNA glycosylases, which initiate the base excision repair pathway, and a conserved helix-hairpin-helix motif and an invariant Asp residue are found in the active sites of more than 20 monofunctional and bifunctional DNA gly cosylases.
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
The results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets.
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil‐DNA glycosylase with DNA
- S. S. Parikh, C. Mol, G. Slupphaug, S. Bharati, H. Krokan, J. Tainer
- Chemistry, BiologyThe EMBO journal
- 1 September 1998
UDG binds to AP sites more tightly and more rapidly than to uracil‐containing DNA, and thus may protect cells sterically from AP site toxicity, and AP site binding may couple damage‐specific and damage‐general steps of BER without requiring direct protein–protein interactions.
Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
It is shown that recessive mutations of the gene encoding uracil–DNA glycosylase (UNG) are associated with profound impairment in CSR at a DNA precleavage step and with a partial disturbance of the SHM pattern in three patients with hyper-IgM syndrome.
Alkylation damage in DNA and RNA--repair mechanisms and medical significance.
Base excision repair.
Base excision repair protects against cancer, aging, and neurodegeneration and takes place both in nuclei and mitochondria and other DNA glycosylases may have important roles in epigenetics, thus expanding the repertoire of BER proteins.
A nucleotide-flipping mechanism from the structure of human uracil–DNA glycosylase bound to DNA
- G. Slupphaug, C. Mol, B. Kavli, A. Arvai, H. Krokan, J. Tainer
- Biology, ChemistryNature
- 7 November 1996
The structure of one of the engineered human UDG mutants represents the first structure of any eukaryotic DNA repair enzyme in complex with its damaged, target DNA and reveals the basis for the enzyme-assisted nucleotide flipping by this critical DNA-repair enzyme.