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Inhibitors of the rate of carbohydrate and lipid absorption by the intestine.
A compound was found which inhibits the absorption of carbohydrates as well as triglycerides, which should cause lower concentrations of fat, glucose and insulin in blood and tissues.
Pharmacokinetics of miglitol. Absorption, distribution, metabolism, and excretion following administration to rats, dogs, and man.
The absorption, distribution, metabolism, and excretion of miglitol have been studied following single and repeated administration of non-labelled and radiolabelled drug to rats, dogs, and human volunteers via different routes of administration and at various doses.
Cerebrovascular effects of the calcium antagonistic dihydropyridine derivative nimodipine in animal experiments.
From its pharmacological properties nimodipine is predicted to be effective in the prevention and therapy of cerebrovascular spasm of various origins and especially in the treatment of postischaemic brain damage.
Pharmacokinetics of acarbose. Part I: Absorption, concentration in plasma, metabolism and excretion after single administration of [14C]acarbose to rats, dogs and man.
The absorption, disposition, metabolism, and excretion of acarbose have been studied following a single administration of the 14C-labelled compound to rats and dogs via different routes (intravenous, oral, intraduodenal) in the dose range of 2-200 mg.
Glucosidase inhibition
Biotransformation of nimodipine in rat, dog, and monkey.
Nimodipine was extensively metabolized and a large number of metabolites was produced by some common biotransformation reactions: dehydrogenation of the 1,4-dihydropyridine system, oxidative ester cleavage, oxidative O-demethylation and subsequent oxidation of the resulting primary alcohol to the carboxylic acid.
Pharmacokinetics of nisoldipine. II. Distribution to and elimination from tissues and organs following single or repeated administration of [14C]nisoldipine to rats and dogs.
No indication was found for a distinct retention of substance-associated radioactivity in organs and tissues in rats and dogs after repeated administration ofnisoldipine.
The pharmacokinetics of nitrendipine. I. Absorption, plasma concentrations, and excretion after single administration of [14C]nitrendipine to rats and dogs.
Distinct sex-differences in the excretion pattern could be found in rats but not in mice, attributed to well-known sex differences of the metabolic capacities in rat liver.
Behavioral effects of nimodipine in animals.
It is concluded that nimodipine besides being a cerebrally vasoactive agent has psychopharmacological properties with a profile of actions hitherto unknown.