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Mediators and moderators of treatment effects in randomized clinical trials.
Randomized clinical trials (RCTs) not only are the gold standard for evaluating the efficacy and effectiveness of psychiatric treatments but also can be valuable in revealing moderators and mediatorsExpand
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The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity.
OBJECTIVE The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing treatments. A primary mandate of theExpand
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Coming to terms with risk factors for eating disorders: application of risk terminology and suggestions for a general taxonomy.
The aims of the present review are to apply a recent risk factor approach (H. C. Kraemer et al., 1997) to putative risk factors for eating disorders, to order these along a timeline, and to deduceExpand
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Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment.
OBJECTIVES To develop a categorical outcome measure related to clinical decisions and to perform secondary analyses to supplement the primary analyses of the NIMH Collaborative Multisite MultimodalExpand
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Coming to terms with the terms of risk.
Terms such as risk, risk factors, and especially the term cause are inconsistently and imprecisely used, fostering scientific miscommunication and misleading research and policy. Clarifying suchExpand
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A new approach to integrating data from multiple informants in psychiatric assessment and research: mixing and matching contexts and perspectives.
OBJECTIVE When there exists no single source of information (informant) to validly measure a characteristic, it is typically recommended that data from multiple informants be used. In psychiatricExpand
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Size of Treatment Effects and Their Importance to Clinical Research and Practice
In randomized clinical trails (RCTs), effect sizes seen in earlier studies guide both the choice of the effect size that sets the appropriate threshold of clinical significance and the rationale toExpand
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ADHD comorbidity findings from the MTA study: comparing comorbid subgroups.
OBJECTIVES Previous research has been inconclusive whether attention-deficit/hyperactivity disorder (ADHD), when comorbid with disruptive disorders (oppositional defiant disorder [ODD] or conductExpand
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How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors.
OBJECTIVE The authors developed a methodological basis for investigating how risk factors work together. Better methods are needed for understanding the etiology of disorders, such as psychiatricExpand
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