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Possible mechanism for zinc protection against cadmium cytotoxicity in cultured vascular endothelial cells.
The mechanism by which zinc protects endothelial cells from Cadmium cytotoxicity was decreased accumulation of cadmium in the particulate fraction and in the high-molecular-weight fraction in the cytosol of the cells. Expand
Inhibitory effects of cadmium on in vitro calcification of a clonal osteogenic cell, MC3T3-E1.
It is suggested that the inhibitory effect of Cd on in vitro calcification of MC3T3-E1 cells may be due to both a depression of cell-mediated calcification and a decrease in physiochemical mineral deposition. Expand
Sensitive response of cultured vascular smooth-muscle cells to cadmium cytotoxicity: comparison with cultured vascular endothelial cells and kidney epithelial LLC-PK1 cells.
The present data suggest that a much lower inducibility of metallothionein with a high accumulation of intracellular cadmium in vascular smooth-muscle cells resulted in a marked sensitivity of the cells to Cadmium cytotoxicity. Expand
Metabolism of 2,4-dinitrotoluene and 2,6-dinitrotoluene, and their dinitrobenzyl alcohols and dinitrobenzaldehydes by Wistar and Sprague-Dawley rat liver microsomal and cytosol fractions.
It was concluded that the dinitrobenzaldehydes (2,4-DNBAl and 2,6-D NBAl) were intermediates in the oxidations of dinitRObenzyl alchols and d initrobenzoic acids of male Wistar and male Sprague-Dawley (S.D.) rat livers. Expand
Interaction of zinc with cadmium and copper on ossification of embryonic chick bone in tissue culture
In spite of the inhibitory effect on calcification, zinc prevented a decrease in bone matrix formation caused by cadmium but not that by copper, which would have resulted in decreased mineralization of bone, with or without suppression of matrix formation. Expand
Effects of clofibric acid and tiadenol on cytosolic long-chain acyl-CoA hydrolase and peroxisomal beta-oxidation in liver and extrahepatic tissues of rats.
The results from the present study suggest that inductions of peroxisomal beta-oxidation and cytosolic long-chain acyl-CoA hydrolases are essential responses of rats toperoxisome proliferators not only in liver but also in intestinal mucosa and that induced hydrolase are not attributable to non-specific esterases. Expand
A suitable culture medium for ossification of embryonic chick femur in organ culture.
The organ culture system using BGJb-HW2 medium supplemented with 5 mM beta-GP induced development of ossification and was considered to be an appropriate one for studies on osteogenesis in vitro. Expand
Preparation of some acetylated, reduced and oxidized derivatives of 2,4-diaminotoluene and 2,6-dinitrotoluene
4-Acetylamino-2-hydroxylaminotoluene (4AA2HAT) and 2-hydroxylamino-6-nitrotoluene (2HA6NT) were prepared from 4-acetylamino-2-nitrotoluene (4AA2NT) and 2, 6-dinitrotoluene (2, 6-DNT), respectively,Expand
Modulation by dietary oils and clofibric acid of arachidonic acid content in phosphatidylcholine in liver and kidney of rat: effects on prostaglandin formation in kidney.
The manipulation of 20:4(n - 6) contents in phosphatidylcholine of liver and kidney of rats by dietary oils and p-chlorophenoxyisobutyric acid (clofibric acid) as well as the effects on the formationExpand
Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids.
Administration of P-chlorophenoxyisobutyric acid (clofibric acid) enhanced in vivo conversion of linoleic acid to its desaturated and/or elongated metabolites, 6,9,12-octadecatrienoic acid, 8,11,14-eicosatrienoIC acid, and arachidonic acid, whereas the formation of 11, 14- eicosadienoic Acid was decreased. Expand